Evidence map›Paper›PMID 24842880›Full record

ArticleThe American journal of tropical medicine and hygiene2014

Current strategic thinking for the development of a trivalent alphavirus vaccine for human use.

Daniel N Wolfe, D Gray Heppner, Shea N Gardner, Crystal Jaing, Lesley C Dupuy, Connie S Schmaljohn, Kevin Carlton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniel N WolfeChemical and Biological Technologies Department, Defense Threat Reduction Agency, Fort Belvoir, Virginia; TASC, Inc., Lorton, Virginia; Computations/Global Security, Lawrence Livermore National Laboratory, Livermore, California; Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California; US Army Medical Research Institute for Infectious Diseases, Fort Detrick, Maryland; Joint Vaccine Acquisition Program, Medical Countermeasure Systems, Joint Program Executive Office, Fort Detrick, Maryland daniel.wolfe@dtra.mil.
D Gray HeppnerChemical and Biological Technologies Department, Defense Threat Reduction Agency, Fort Belvoir, Virginia; TASC, Inc., Lorton, Virginia; Computations/Global Security, Lawrence Livermore National Laboratory, Livermore, California; Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California; US Army Medical Research Institute for Infectious Diseases, Fort Detrick, Maryland; Joint Vaccine Acquisition Program, Medical Countermeasure Systems, Joint Program Executive Office, Fort Detrick, Maryland.
Shea N GardnerChemical and Biological Technologies Department, Defense Threat Reduction Agency, Fort Belvoir, Virginia; TASC, Inc., Lorton, Virginia; Computations/Global Security, Lawrence Livermore National Laboratory, Livermore, California; Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California; US Army Medical Research Institute for Infectious Diseases, Fort Detrick, Maryland; Joint Vaccine Acquisition Program, Medical Countermeasure Systems, Joint Program Executive Office, Fort Detrick, Maryland.
Crystal JaingChemical and Biological Technologies Department, Defense Threat Reduction Agency, Fort Belvoir, Virginia; TASC, Inc., Lorton, Virginia; Computations/Global Security, Lawrence Livermore National Laboratory, Livermore, California; Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California; US Army Medical Research Institute for Infectious Diseases, Fort Detrick, Maryland; Joint Vaccine Acquisition Program, Medical Countermeasure Systems, Joint Program Executive Office, Fort Detrick, Maryland.
Lesley C DupuyChemical and Biological Technologies Department, Defense Threat Reduction Agency, Fort Belvoir, Virginia; TASC, Inc., Lorton, Virginia; Computations/Global Security, Lawrence Livermore National Laboratory, Livermore, California; Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California; US Army Medical Research Institute for Infectious Diseases, Fort Detrick, Maryland; Joint Vaccine Acquisition Program, Medical Countermeasure Systems, Joint Program Executive Office, Fort Detrick, Maryland.
Connie S SchmaljohnChemical and Biological Technologies Department, Defense Threat Reduction Agency, Fort Belvoir, Virginia; TASC, Inc., Lorton, Virginia; Computations/Global Security, Lawrence Livermore National Laboratory, Livermore, California; Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California; US Army Medical Research Institute for Infectious Diseases, Fort Detrick, Maryland; Joint Vaccine Acquisition Program, Medical Countermeasure Systems, Joint Program Executive Office, Fort Detrick, Maryland.
Kevin CarltonChemical and Biological Technologies Department, Defense Threat Reduction Agency, Fort Belvoir, Virginia; TASC, Inc., Lorton, Virginia; Computations/Global Security, Lawrence Livermore National Laboratory, Livermore, California; Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California; US Army Medical Research Institute for Infectious Diseases, Fort Detrick, Maryland; Joint Vaccine Acquisition Program, Medical Countermeasure Systems, Joint Program Executive Office, Fort Detrick, Maryland.
Lawrence Livermore National Laboratory · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccinations against the encephalitic alphaviruses (western, eastern, and Venezuelan equine encephalitis virus) are of significant interest to biological defense, public health, and agricultural communities alike. Although vaccines licensed for veterinary applications are used in the Western Hemisphere and attenuated or inactivated viruses have been used under Investigational New Drug status to protect at-risk personnel, there are currently no licensed vaccines for use in humans. Here, we will discuss the need for a trivalent vaccine that can protect humans against all three viruses, recent progress to such a vaccine, and a strategy to continue development to Food and Drug Administration licensure.

Indexed as

Viral VaccinesAlphavirusAlphavirus InfectionsAnimalsEncephalitis, ViralEncephalitis Virus, Eastern EquineEncephalitis Virus, Venezuelan EquineEncephalitis Virus, Western EquineHumansSequence AlignmentVaccinationViral Vaccines

Identifiers

PMID24842880
PMCPMC4155543
OpenAlexW2112441450

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.