ArticleJournal of the American Academy of Dermatology2014
Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract.
Article in Journal of the American Academy of Dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Vulvar Malignant Melanoma: A Narrative Review.Cancers · 2022Review
- Urethral Melanoma - Clinical, Pathological and Molecular Characteristics.Bladder cancer (Amsterdam, Netherlands) · 2022Article
- Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.American journal of clinical dermatology · 2021Review
- Article
- Cutaneous and Mucosal Melanomas of Uncommon Sites: Where Do We Stand Now?Journal of clinical medicine · 2021Review
- The mutational landscape of mucosal melanoma.Seminars in cancer biology · 2020Review
- Predictive biomarkers and tumor microenvironment in female genital melanomas: a multi-institutional study of 55 cases.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- AtypicalCancers · 2019Review
- Label-Free Imaging of Female Genital Tract Melanocytic Lesions With Pump-Probe Microscopy: A Promising Diagnostic Tool.Journal of lower genital tract disease · 2017Article
- Identification of recurrent mutational events in anorectal melanoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- Nonoverlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi.The Journal of investigative dermatology · 2016Review
- Biologically distinct subsets of nevi.Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia · 2016Review
- Low mutational burden of eight genes involved in the MAPK/ERK, PI3K/AKT, and GNAQ/11 pathways in female genital tract primary melanomas.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe genetic heterogeneity of melanomas and melanocytic nevi of the female genital tract is poorly understood.
objectiveWe aim to characterize the frequency of mutations of the following genes: BRAF, NRAS, KIT, GNA11, and GNAQ in female genital tract melanomas. We also characterize the frequency of BRAF mutations in female genital tract melanomas compared with melanocytic nevi.
methodsMutational screening was performed on the following female genital tract melanocytic neoplasms: 25 melanomas, 7 benign melanocytic nevi, and 4 atypical melanocytic nevi.
resultsOf the 25 female genital tract melanoma specimens queried, KIT mutations were detected in 4 (16.0%), NRAS mutations in 4 (16.0%), and BRAF mutations in 2 (8.0%) samples. Two of the tumors with KIT mutations harbored double mutations in the same exon. No GNAQ or GNA11 mutations were identified among 11 melanomas screened. BRAF V600E mutations were detected in 7 of 7 benign melanocytic genital nevi (100%) and 3 of 4 atypical genital nevi (75%). LIMITATIONS: Our study is limited by the small sample size of this rare subset of melanomas.
conclusionKIT, NRAS, and BRAF mutations are found in a subset of female genital tract melanomas. Screening for oncogenic mutations is important for developing and applying clinical therapies for melanomas of the female genital tract.
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