Evidence map›Paper›PMID 24842673›Full record

ArticleFertility and sterility2014

No increase in autism-associated genetic events in children conceived by assisted reproduction.

Sean Ackerman, Julia Wenegrat, David Rettew, Robert Althoff, Raphael Bernier

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Fertility and sterility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Bio-collections in autism research.Molecular autism · 2017
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sean AckermanDepartment of Psychiatry, School of Medicine, University of Vermont, Burlington, Vermont. Electronic address: sean.ackerman@vtmednet.org.
Julia WenegratDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle, Washington.
David RettewDepartment of Psychiatry, School of Medicine, University of Vermont, Burlington, Vermont.
Robert AlthoffDepartment of Psychiatry, School of Medicine, University of Vermont, Burlington, Vermont.
Raphael BernierDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle, Washington.

Funding

Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI GARDEN, GWENN A · 2014 to 2019
$7.9M
Phenotypic Characterization of Gene Disrupting Mutations in ASDR01MH100047 · NIMH · UNIVERSITY OF WASHINGTON · PI BERNIER, RAPHAEL A · 2014 to 2018
$2.1M
NICHD NIH HHS U54 HD083091NIMH NIH HHS R01 MH100047
6 · The paper itself

Abstract

objectiveTo understand the rate of genetic events in patients with autism spectrum disorder (ASD) who were exposed to assisted reproduction.

designCase control study using genetics data.

settingTwelve collaborating data collection sites across North America as part of the Simons Simplex Collection. PATIENT(S): 2,760 children with ASD, for whom 1,994 had published copy number variation data and 424 had published gene mutation status available. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Rates of autism-associated genetic events in children with ASD conceived with assisted reproduction versus those conceived naturally. RESULT(S): No statistically significant differences in copy number variations or autism-associated gene-disrupting events were found when comparing ASD patients exposed to assisted reproduction with those not exposed to assisted reproduction. CONCLUSION(S): This is the first large genetic association to concurrently examine the genotype of individuals with ASD in relation to their exposure to ART versus natural conception, and it adds reassuring evidence to the argument that ART does not increase the risk of ASD.

Indexed as

DNA Copy Number VariationsGene DosageMutationAdolescentCase-Control StudiesChildChild Development Disorders, PervasiveChild, PreschoolGenetic Association StudiesGenetic Predisposition to DiseaseHumansNorth AmericaReproductive Techniques, AssistedRisk AssessmentRisk FactorsAssisted reproductionassisted reproductive technologyautismcopy number variation

Identifiers

PMID24842673
PMCPMC5808861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.