Evidence map›Paper›PMID 24842491›Full record

Trial reportBlood pressure monitoring2014

Reproducibility of masked hypertension among adults 30 years or older.

Anthony J Viera, Feng-Chang Lin, Laura A Tuttle, Emily Olsson, Kristin Stankevitz, Susan S Girdler, J Larry Klein, Alan L Hinderliter

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Blood pressure monitoring, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03872856 (Home Blood Pressure Monitoring Intervention for Self-Management of High Blood Pressure Among Alaska Native People), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03872856 nacompletednot on this mapstarted 2019, after this paper: background citation

Home Blood Pressure Monitoring Intervention for Self-Management of High Blood Pressure Among Alaska Native People

TypeinterventionalSponsorSouthcentral FoundationRan2019 to 2023Enrolled164ConditionsHypertensionArmsBP-ICAN
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. The role of wearable home blood pressure monitoring in detecting out-of-office control status.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Observational
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Blood pressure cutoffs for white-coat and masked effects in a large population undergoing home blood pressure monitoring.Hypertension research : official journal of the Japanese Society of Hypertension · 2019
    Article
  11. Article
  12. Observational
  13. Review
  14. Review
  15. Article
  16. Article
  17. Implementing ABPM into Clinical Practice.Current hypertension reports · 2018
    Review
  18. Association of ambulatory blood pressure variability with coronary artery calcium.Journal of clinical hypertension (Greenwich, Conn.) · 2018
    Article
  19. An Update on Masked Hypertension.Current hypertension reports · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anthony J VieraDepartments of aFamily Medicine bMedicine - Division of Cardiology cPsychiatry, University of North Carolina School of Medicine dHypertension Research Program, University of North Carolina at Chapel Hill eDepartment of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, USA.
Feng-Chang Lin
Laura A Tuttle
Emily Olsson
Kristin Stankevitz
Susan S Girdler
J Larry Klein
Alan L Hinderliter

Funding

UNC CLINICAL AND TRANSLATIONAL SCIENCE AWARD: BPCAUL1RR025747 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2008 to 2011
$44.6M
Reproducibility and Clinical Implications of Masked HypertensionR01HL098604 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI VIERA, ANTHONY J · 2010 to 2012
$1.9M
NCRR NIH HHS UL1 RR025747NHLBI NIH HHS R01 HL098604
6 · The paper itself

Abstract

objectiveMasked hypertension (MH) refers to nonelevated office blood pressure (BP) with elevated out-of-office BP, but its reproducibility has not been conclusively established. We examined 1-week reproducibility of MH by home BP monitoring (HBPM) and ambulatory BP monitoring (ABPM).

methodsWe recruited 420 adults not on BP-lowering medication, with recent clinic BP between 120/80 and 149/95 mmHg. For main comparisons, participants with office average less than 140/90 mmHg were considered to have MH if awake ABPM average was 135/85 mmHg or higher; they were considered to have MH by HBPM if the average was 135/85 mmHg or higher. Percentage agreements were quantified in terms of κ. We also examined the prevalence of MH, defined as office average less than 140/90 mmHg, with a 24-h ABPM average of 130/80 mmHg or higher. We carried out sensitivity analyses using different threshold BP levels for ABPM-office pairings and HBPM-office pairings for defining MH.

resultsPrevalence rates of MH based on office-awake ABPM pairings were 44 and 43%, with an agreement of 71% (κ=0.40; 95% confidence interval 0.31-0.49). MH was less prevalent (15 and 17%) using HBPM-office pairings, with agreement of 82% (κ=0.30; 95% confidence interval 0.16-0.44), and more prevalent when considering the 24-h average (50 and 48%). MH was also less prevalent when more stringent diagnostic criteria were applied. Office-HBPM pairings and office-awake ABPM pairings had fair agreement on MH classification on both occasions, with κ-values of 0.36 and 0.30.

conclusionMH has fair short-term reproducibility, providing further evidence that for some people, out-of-office BP is systematically higher than that measured in the office setting.

Indexed as

Blood PressureBlood Pressure Monitoring, AmbulatoryAdultAge FactorsFemaleHumansHypertensionMaleMiddle AgedPrevalenceReproducibility of Results

Identifiers

PMID24842491
PMCPMC4625914

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.