ArticleIranian biomedical journal2014
Gating behavior of endoplasmic reticulum potassium channels of rat hepatocytes in diabetes.
Article in Iranian biomedical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
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- Diet Modulation Restores Autophagic Flux in Damaged Skeletal Muscle Cells.The journal of nutrition, health & aging · 2019Article
- Monocyte Response to DifferentToxins · 2018Article
- Endoplasmic reticulum membrane potassium channel dysfunction in high fat diet induced stress in rat hepatocytes.EXCLI journal · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
backgroundDefects in endoplasmic reticulum homeostasis are common occurrences in different diseases, such as diabetes, in which the function of endoplasmic reticulum is disrupted. It is now well established that ion channels of endoplasmic reticulum membrane have a critical role in endoplasmic reticulum luminal homeostasis. Our previous studies showed the presence of an ATP-sensitive cationic channel in endoplasmic reticulum. Therefore, in this study, we examined and compared the activities of this channel in control and diabetic rats using single-channel recording techniques.
methodMale Wistar rats were made diabetic for 2 weeks with a single dose injection of streptozotocin (45 mg/kg). Ion channel incorporation of rough endoplasmic reticulum of diabetic hepatocytes into the bilayer lipid membrane allowed the characterization of K+ channel.
resultsIon channel incorporation of rough endoplasmic reticulum vesicles into the bilayer lipid revealed that the channel current-voltage (I-V) relation with a mean slope conductance of 520 ± 19 pS was unaffected in diabetes. Interestingly, the channel Po-voltage relation was significantly lower in diabetic rats at voltages above +30 mV.
conclusionWe concluded that the endoplasmic reticulum cationic channel is involved in diabetes. Also, this finding could be considered as a goal for further therapeutic plans.
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