Evidence map›Paper›PMID 24842004›Full record

ArticleBrain research2014

Striatal enkephalinergic differences in rats selectively bred for intrinsic running capacity.

Derek C Monroe, Philip V Holmes, Lauren G Koch, Steven L Britton, Rodney K Dishman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Sex-dependent differences in voluntary physical activity.Journal of neuroscience research · 2017
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Derek C MonroeDepartment of Kinesiology, University of Georgia, 330 River Road, Athens, GA 30602-6554, USA. Electronic address: dmon@uga.edu.
Philip V HolmesPsychology Department, University of Georgia, Athens, GA, USA. Electronic address: pvholmes@uga.edu.
Lauren G KochDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA. Electronic address: lgkoch@med.umich.edu.
Steven L BrittonDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA. Electronic address: brittons@med.umich.edu.
Rodney K DishmanDepartment of Kinesiology, University of Georgia, 330 River Road, Athens, GA 30602-6554, USA. Electronic address: rdishman@uga.edu.
University of Georgia · USUniversity of Michigan–Ann Arbor · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
RESOURCE FOR RAT GENETIC MODELS OF AEROBIC CAPACITYR24RR017718 · NCRR · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI BRITTON, STEVEN LOYAL · 2003 to 2011
$4.0M
Biology of Aerobic Capacity and Insulin ResistanceR01DK077200 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2008 to 2012
$1.5M
Inflammation resolving mechanism dysregulation in postoperative cognitive declineR01GM104194 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAZE, MERVYN · 2013 to 2016
$1.2M
Resource for Rat Genetic Models of Aerobic CapacityR24OD010950 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRITTON, STEVEN LOYAL · 2012 to 2013
$1.0M
NCRR NIH HHS R24 RR017718NCRR NIH HHS R24RR017718NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK077200NIDDK NIH HHS R01DK077200NIGMS NIH HHS R01 GM104194NIGMS NIH HHS R01GM104194NIH HHS R24 OD010950NIH HHS R24OD010950
6 · The paper itself

Abstract

unlabelledRats selectively bred for high- and low-capacity for running on a treadmill (HCR; LCR) also differ in wheel-running behavior, but whether wheel-running can be explained by intrinsic or adaptive brain mechanisms is not as yet understood. It is established that motivation of locomotory behavior is driven by dopaminergic transmission in mesolimbic and mesostriatal systems. However, whether voluntary wheel running is associated with enkephalinergic activity in the ventral striatum is not known. MATERIALS AND

methods40 male (20 HCR and 20 LCR) and 40 female (20 HCR and 20 LCR) rats were randomly assigned to 3 weeks of activity wheel exposure or sedentary conditions without wheel access. After 3 weeks of activity-wheel running, rats were decapitated and brains were extracted. Coronal sections were analyzed utilizing in situ hybridization histochemistry for enkephalin (ENK) mRNA in the ventral striatum.

resultsHCR rats expressed less ENK than LCR rats in the nucleus accumbens among females (p<0.01) and in the olfactory tubercle among both females (p<0.05) and males (p<0.05). There was no effect of wheel running on ENK mRNA expression.

conclusionLine differences in ENK expression in the olfactory tubercle, and possibly the nucleus accumbens, partly explain divergent wheel-running behavior. The lower striatal ENK in the HCR line is consistent with enhanced dopaminergic tone, which may explain the increased motivation for wheel running observed in the HCR line.

Indexed as

Motor ActivityAnimalsEnkephalinsFemaleMaleNucleus AccumbensOlfactory TubercleRatsRNA, MessengerRunningVentral StriatumEnkephalinsRNA, MessengerActivity wheelEnkephalinIn situ hybridizationNucleus accumbensOlfactory tubercle

Identifiers

PMID24842004
PMCPMC4126082
OpenAlexW2089759487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.