ArticleThe Journal of cell biology2014
PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo.
Article in The Journal of cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Pooled it
- Initial characterization of gap phase introduction in every cell cycle ofFrontiers in cell and developmental biology · 2022Article
- Perspectives on Mechanisms Supporting Neuronal Polarity From Small Animals to Humans.Frontiers in cell and developmental biology · 2022Review
- Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans.PLoS genetics · 2020Article
- PLK-1 Regulation of Asymmetric Cell Division in the EarlyFrontiers in cell and developmental biology · 2020Review
- Spindle assembly checkpoint strength is linked to cell fate in the Caenorhabditis elegans embryo.Molecular biology of the cell · 2018Article
- LKB1-AMPK modulates nutrient-induced changes in the mode of division of intestinal epithelial crypt cells in mice.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2016Article
- Cyclin CYB-3 controls both S-phase and mitosis and is asymmetrically distributed in the early C. elegans embryo.Development (Cambridge, England) · 2016Article
- Article
- Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.International journal of cancer · 2015Article
- PAR-4 and anillin regulate myosin to coordinate spindle and furrow position during asymmetric division.The Journal of cell biology · 2015Article
- Non-coding stem-bulge RNAs are required for cell proliferation and embryonic development in C. elegans.Journal of cell science · 2015Article
- CDK-1 and two B-type cyclins promote PAR-6 stabilization during polarization of the early C. elegans embryo.PloS one · 2015Article
- Power law relationship between cell cycle duration and cell volume in the early embryonic development of Caenorhabditis elegans.Frontiers in physiology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Regulation of cell cycle duration is critical during development, yet the underlying molecular mechanisms are still poorly understood. The two-cell stage Caenorhabditis elegans embryo divides asynchronously and thus provides a powerful context in which to study regulation of cell cycle timing during development. Using genetic analysis and high-resolution imaging, we found that deoxyribonucleic acid (DNA) replication is asymmetrically regulated in the two-cell stage embryo and that the PAR-4 and PAR-1 polarity proteins dampen DNA replication dynamics specifically in the posterior blastomere, independently of regulators previously implicated in the control of cell cycle timing. Our results demonstrate that accurate control of DNA replication is crucial during C. elegans early embryonic development and further provide a novel mechanism by which PAR proteins control cell cycle progression during asynchronous cell division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.