ArticlePloS one2014
Raman spectroscopic study of radioresistant oral cancer sublines established by fractionated ionizing radiation.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
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- Nano-Topography Enhanced Topological-Cell-Analysis in Radiation-Therapy.Advanced healthcare materials · 2025Review
- Human Cancer Cell Radiation Response Investigated through Topological Analysis of 2D Cell Networks.Annals of biomedical engineering · 2023Article
- Raman Spectroscopy Revealed Cell Passage-Dependent Distinct Biochemical Alterations in Radiation-Resistant Breast Cancer Cells.ACS omega · 2023Article
- Raman spectroscopy and convolutional neural networks for monitoring biochemical radiation response in breast tumour xenografts.Scientific reports · 2023Article
- Human lung-cancer-cell radioresistance investigated through 2D network topology.Scientific reports · 2022Article
- Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases.Frontiers in cellular and infection microbiology · 2022Review
- Alpelisib and radiotherapy treatment enhances Alisertib-mediated cervical cancer tumor killing.American journal of cancer research · 2021Article
- Silencing Snail Reverses Epithelial-Mesenchymal Transition and Increases Radiosensitivity in Hypopharyngeal Carcinoma.OncoTargets and therapy · 2020Article
- Discrimination of radiosensitive and radioresistant murine lymphoma cells by Raman spectroscopy and SERS.Biomedical optics express · 2020Article
- RAC1 Involves in the Radioresistance by Mediating Epithelial-Mesenchymal Transition in Lung Cancer.Frontiers in oncology · 2020Article
- Exploring subcellular responses of prostate cancer cells to X-ray exposure by Raman mapping.Scientific reports · 2019Article
- Raman spectroscopy detects metabolic signatures of radiation response and hypoxic fluctuations in non-small cell lung cancer.BMC cancer · 2019Article
- Optical Imaging Approaches to Investigating Radiation Resistance.Frontiers in oncology · 2019Review
- Upcoming imaging concepts and their impact on treatment planning and treatment response in radiation oncology.Radiation oncology (London, England) · 2018Article
- IL-6/STAT3/TWIST inhibition reverses ionizing radiation-induced EMT and radioresistance in esophageal squamous carcinoma.Oncotarget · 2017Article
- Unique spectral markers discern recurrent Glioblastoma cells from heterogeneous parent population.Scientific reports · 2016Article
- Raman spectroscopy identifies radiation response in human non-small cell lung cancer xenografts.Scientific reports · 2016Article
- Ribonucleic acid (RNA) biosynthesis in human cancer.Cancer cell international · 2015Article
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Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy is an important treatment modality for oral cancer. However, development of radioresistance is a major hurdle in the efficacy of radiotherapy in oral cancer patients. Identifying predictors of radioresistance is a challenging task and has met with little success. The aim of the present study was to explore the differential spectral profiles of the established radioresistant sublines and parental oral cancer cell lines by Raman spectroscopy. We have established radioresistant sublines namely, 50Gy-UPCI:SCC029B and 70Gy-UPCI:SCC029B from its parental UPCI:SCC029B cell line, by using clinically admissible 2Gy fractionated ionizing radiation (FIR). The developed radioresistant character was validated by clonogenic cell survival assay and known radioresistance-related protein markers like Mcl-1, Bcl-2, Cox-2 and Survivin. Altered cellular morphology with significant increase (p<0.001) in the number of filopodia in radioresistant cells with respect to parental cells was observed. The Raman spectra of parental UPCI:SCC029B, 50Gy-UPCI:SCC029B and 70Gy-UPCI:SCC029B cells were acquired and spectral features indicate possible differences in biomolecules like proteins, lipids and nucleic acids. Principal component analysis (PCA) provided three clusters corresponding to radioresistant 50Gy, 70Gy-UPCI:SCC029B sublines and parental UPCI:SCC029B cell line with minor overlap, which suggest altered molecular profile acquired by the radioresistant cells due to multiple doses of irradiation. The findings of this study support the potential of Raman spectroscopy in prediction of radioresistance and possibly contribute to better prognosis of oral cancer.
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