ArticleCardiovascular research2014
Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations.
Article in Cardiovascular research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Influence of wall distensibility on local hemodynamics at the normal carotid bifurcation: a fluid-structure interaction study.Biomechanics and modeling in mechanobiology · 2026Article
- Time and architecture: the next two dimensions of microphysiological systems.npj biomedical innovations · 2026Review
- Innovative Atherosclerosis Models: Advancing Pathophysiology and Translational Research.Research (Washington, D.C.) · 2025Review
- Clot Accumulation in 3D Microfluidic Bifurcating Microvasculature Network.Micromachines · 2024Article
- Haemodynamic changes in visceral hybrid repairs of type III and type V thoracoabdominal aortic aneurysms.Scientific reports · 2023Article
- Reducing Long-Term Mortality Post Transcatheter Aortic Valve Replacement Requires Systemic Differentiation of Patient-Specific Coronary Hemodynamics.Journal of the American Heart Association · 2023Article
- An optical coherence tomography and endothelial shear stress study of a novel bioresorbable bypass graft.Scientific reports · 2023Article
- Influence of Rigid-Elastic Artery Wall of Carotid and Coronary Stenosis on Hemodynamics.Bioengineering (Basel, Switzerland) · 2022Article
- Dissecting the complexities of Alzheimer disease with in vitro models of the human brain.Nature reviews. Neurology · 2022Review
- Combining 4D Flow MRI and Complex Networks Theory to Characterize the Hemodynamic Heterogeneity in Dilated and Non-dilated Human Ascending Aortas.Annals of biomedical engineering · 2021Article
- Emulating Early Atherosclerosis in a Vascular Microphysiological System Using Branched Tissue-Engineered Blood Vessels.Advanced biology · 2021Article
- Bridging the Gap in a Rare Cause of Angina.European cardiology · 2021Review
- Wall Shear Stress Topological Skeleton Independently Predicts Long-Term Restenosis After Carotid Bifurcation Endarterectomy.Annals of biomedical engineering · 2020Article
- Mechanisms of endothelial stiffening in dyslipidemia and aging: Oxidized lipids and shear stress.Current topics in membranes · 2020Review
- Segment-specific associations between local haemodynamic and imaging markers of early atherosclerosis at the carotid artery: anJournal of the Royal Society, Interface · 2018Article
- Chondroitin Sulphate Attenuates Atherosclerosis in ApoE Knockout Mice Involving Cellular Regulation of the Inflammatory Response.Thrombosis and haemostasis · 2018Article
- Arterial pulse attenuation prediction using the decaying rate of a pressure wave in a viscoelastic material model.Biomechanics and modeling in mechanobiology · 2018Article
- Determination of hemodynamic risk for vascular disease in planar artery bifurcations.Scientific reports · 2018Article
- Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
aimsAtherogenesis, evolution of plaque, and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multiscale models able to correlate changes in microscopic cellular responses with relevant macroscopic flow, and structural conditions may help understand the progression of occlusive arterial disease, providing insights into how to mitigate adverse responses in specific settings and individuals. METHODS AND
resultsVascular architectures mimicking coronary and carotid bifurcations were derived from clinical imaging and used to generate conjoint computational meshes for in silico analysis and biocompatible scaffolds for in vitro models. In parallel with three-dimensional flow simulations, geometrically realistic scaffolds were seeded with human smooth muscle cells (SMC) or endothelial cells and exposed to relevant, physiological flows. In vitro surrogates of endothelial health, atherosclerotic progression, and thrombosis were locally quantified and correlated best with an quantified extent of flow recirculation occurring within the bifurcation models. Oxidized low-density lipoprotein uptake, monocyte adhesion, and tissue factor expression locally rose up to three-fold, and phosphorylated endothelial nitric oxide synthase and Krüppel-like factor 2 decreased up to two-fold in recirculation areas. Isolated testing in straight-tube idealized constructs subject to static, oscillatory, and pulsatile conditions, indicative of different recirculant conditions corroborated these flow-mediated dependencies.
conclusionsFlow drives variations in vascular reactivity and vascular beds. Endothelial health was preserved by arterial flow but jeopardized in regions of flow recirculation in a quasi-linear manner. Similarly, SMC exposed to flow were more thrombogenic in large recirculating regions. Health, thrombosis, and atherosclerosis biomarkers correlate with the extent of recirculation in vascular cells lining certain vascular geometries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.