ReviewReproductive sciences (Thousand Oaks, Calif.)2014
Synergy and interactions among biological pathways leading to preterm premature rupture of membranes.
Review in Reproductive sciences (Thousand Oaks, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Nomogram model for predicting spontaneous preterm birth in twin pregnancies: a case-control study.BMC pregnancy and childbirth · 2026Article
- A new perspective on predicting latency period in preterm premature rupture of membranes: the role of cervical area measurement.Irish journal of medical science · 2026Article
- The Role of the Vaginal Microbiome in Preterm Premature Rupture of Membranes: A Comprehensive Review of Mechanisms and Clinical Implications.Health science reports · 2025Article
- Comparison between hyperechoic and normo-echoic amniotic membranes in patients with preterm premature rupture of membranes regarding pregnancy outcome.Archives of gynecology and obstetrics · 2025Article
- Buprenorphine induces human fetal membrane sterile inflammation.Journal of reproductive immunology · 2025Article
- Association of exposure to PMFrontiers in public health · 2025Article
- Interaction of vaginal microbiota and biomarkers in Premature rupture of membranes: from bench to beside.Frontiers in immunology · 2025Review
- Perinatal outcomes among pregnant patients with peripartum coronavirus disease 2019 infection.Archives of gynecology and obstetrics · 2024Article
- The relationships of inflammatory blood markers with maternal periodontal and dental states and their effects on preterm membrane rupture development.BMC oral health · 2024Article
- CX3CL1/Fractalkine as a biomarker for early pregnancy prediction of preterm premature rupture of membranes.Clinical chemistry and laboratory medicine · 2024Article
- Frontiers in the Etiology and Treatment of Preterm Premature Rupture of Membrane: From Molecular Mechanisms to Innovative Therapeutic Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Transcriptomic analysis delineates preterm prelabor rupture of membranes from preterm labor in preterm fetal membranes.BMC medical genomics · 2024Article
- FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition.Current medical science · 2024Article
- mRNA and Protein Expression in Human Fetal Membrane Cells: Potential Biomarkers for Preterm Prelabor Rupture of the Fetal Membranes?International journal of molecular sciences · 2023Article
- Exploring Plasma-Level Gut Microbiota Mediators and Pro-Inflammatory Markers in Pregnant Women with Short Cervix and Gestational Diabetes Mellitus.International journal of molecular sciences · 2023Article
- Extreme Temperature Exposure and Risks of Preterm Birth Subtypes Based on a Nationwide Survey in China.Environmental health perspectives · 2023Article
- Combined Application of Exosomes and FPR2 Agonist LXA4 in Controlling Fetal Membrane Inflammation and Promoting Fetal Membrane Tissue Repair.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Prenatal Exposure to Air Pollution and Pre-Labor Rupture of Membranes in a Prospective Cohort Study: The Role of Maternal Hemoglobin and Iron Supplementation.Environmental health perspectives · 2023Article
- The role of extreme heat exposure on premature rupture of membranes in Southern California: A study from a large pregnancy cohort.Environment international · 2023Article
- Matrix metalloproteinases in preterm prelabor rupture of membranes in the setting of chorioamnionitis: A scoping review.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Preterm premature rupture of membranes (PPROM) occurs in 1% to 2% of births. Impact of PPROM is greatest in low- and middle-income countries where prematurity-related deaths are most common. Recent investigations identify cytokine and matrix metalloproteinase activation, oxidative stress, and apoptosis as primary pathways to PPROM. These biological processes are initiated by heterogeneous etiologies including infection/inflammation, placental bleeding, uterine overdistention, and genetic polymorphisms. We hypothesize that pathways to PPROM overlap and act synergistically to weaken membranes. We focus our discussion on membrane composition and strength, pathways linking risk factors to membrane weakening, and future research directions to reduce the global burden of PPROM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.