ArticleJournal of the American Chemical Society2014
Toward a chemical marker for inflammatory disease: a fluorescent probe for membrane-localized thioredoxin.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 84 citations in OpenAlex.
- Insights into the activation patterns of 1,2-dithiolane unit in biofunctional molecules.Nature communications · 2026Article
- A Diimidazole-Based Amphiphilic Probe for Wash-Free Cell Plasma Membrane Imaging.Journal of fluorescence · 2025Article
- Charge-regulated fluorescent anchors enable high-fidelity tracking of plasma membrane dynamics during biological events.Chemical science · 2024Article
- Fluorescent Probes for Mammalian Thioredoxin Reductase: Mechanistic Analysis, Construction Strategies, and Future Perspectives.Biosensors · 2023Review
- Cell membranes targeted unimolecular prodrug for programmatic photodynamic-chemo therapy.Theranostics · 2021Article
- A Diselenide Turn-On Fluorescent Probe for the Detection of Thioredoxin Reductase.Angewandte Chemie (International ed. in English) · 2020Article
- Porphyrinoid Drug Conjugates.Chem · 2020Article
- Cancer-Specific hNQO1-Responsive Biocompatible Naphthalimides Providing a Rapid Fluorescent Turn-On with an Enhanced Enzyme Affinity.Sensors (Basel, Switzerland) · 2019Article
- A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage.Nature communications · 2019Article
- A cell membrane-anchored fluorescent probe for monitoring carbon monoxide release from living cells.Chemical science · 2019Article
- A specific fluorescent probe reveals compromised activity of methionine sulfoxide reductases in Parkinson's disease.Chemical science · 2017Article
- Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules.Chemical Society reviews · 2015Review
- Mitochondria-immobilized pH-sensitive off-on fluorescent probe.Journal of the American Chemical Society · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Thioredoxin (Trx) is a redox-active protein that plays a key role in mitigating the effects of oxidative stress. The secretion of Trx on the plasma membrane has been suggested as a distinctive feature of inflammation. However, selective monitoring of membrane-associated Trx activity has proved challenging because of the ubiquity of Trx action in cells. Here, we report a Trx-specific probe that allows visualization of Trx activity associated with the membranes via fluorescence microscopy. The ability of this probe to act as a possible screening tool for agents that modulate Trx secretion was demonstrated in HeLa cells under oxidative stress conditions and in a cellular hepatosteatosis model. Control experiments serve to confirm that the response seen for the present probe is due to Trx and that it is selective over various potentially competing metabolites, including thiol-containing small molecules and test proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.