Evidence map›Paper›PMID 24840899›Full record

SynthesisMolecules (Basel, Switzerland)2014

Increased circulating microRNA-155 as a potential biomarker for breast cancer screening: a meta-analysis.

Faliang Wang, Jinchao Hou, Wei Jin, Jiaqiu Li, Yongfang Yue, Hongchuan Jin, Xian Wang

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Diagnostic value of circulating microRNAs as biomarkers for breast cancer: a meta-analysis study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Pooled it
  6. Pooled it
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. MicroRNAs as biomarkers for clinical studies.Experimental biology and medicine (Maywood, N.J.) · 2018
    Review
  16. Small Molecules in Rare Tumors: Emerging Role of MicroRNAs in GIST.International journal of molecular sciences · 2018
    Review
  17. Expression of the circulating and the tissue microRNAs after surgery, chemotherapy, and radiotherapy in mice mammary tumor.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  18. New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies.International journal of molecular sciences · 2016
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Faliang WangLaboratory of Cancer Biology, Institute of Clinical Science, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. wangfaliang052@163.com.
Jinchao HouDepartment of Anesthesiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. houjc_8585@163.com.
Wei JinDepartment of Clinical Oncology, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. 21118179@zju.edu.cn.
Jiaqiu LiDepartment of Clinical Oncology, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. lijiaqiu12@163.com.
Yongfang YueLaboratory of Cancer Biology, Institute of Clinical Science, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. jackie-yue@163.com.
Hongchuan JinLaboratory of Cancer Biology, Institute of Clinical Science, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. jinhc@zju.edu.cn.
Xian WangDepartment of Clinical Oncology, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China. wangxzju@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this meta-analysis was to determine the diagnostic accuracy of circulating microRNA-155 (miR-155) for breast cancer (BC). PubMed, Embase, EBSCO (ASP/BSP), Cochrane Library and China National Knowledge Infrastructure (CNKI) were searched up to 30 January 2014 for eligible studies. Quality Assessment of Diagnostic Accuracy Studies (QUADAS) was employed to assess the quality of the included studies. Meta-analysis were performed in Meta-Disc 1.4 and Stata 12.0. Three studies with total 184 BC patients and 75 control individuals were included in this meta-analysis. All of the included studies are of high quality (QUADAS scores 12 or 13). The summary estimates revealed that the pooled sensitivity is 79% (95% confidence interval (CI): 72%-84%) and the specificity is 85% (95% CI: 75%-92%), for the diagnosis of breast cancer. In addition, the area under the summary ROC curve (AUC) is 0.9217. The current evidence suggests that circulating miR-155 has the potential diagnostic value with a high sensitivity and specificity for BC. More prospective studies on the diagnostic value of circulating miR-155 for BC are needed in the future.

Indexed as

Biomarkers, TumorBreast NeoplasmsChinaEarly Detection of CancerFemaleHumansMicroRNAsBiomarkers, TumorMicroRNAsMIRN155 microRNA, human

Identifiers

PMID24840899
PMCPMC6270988

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.