Evidence map›Paper›PMID 24840803›Full record

ReviewNature reviews. Neuroscience2014

Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective.

David L Pauls, Amitai Abramovitch, Scott L Rauch, Daniel A Geller

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 318 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
318citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06566781 recruitingnot on this mapstarted 2019, after this paper: background citation

Reinforcement Learning and Obsessive-compulsive Disorder: Exploring the Role of the Orbitofrontal Cortex

TypeobservationalSponsorFundacao ChampalimaudRan2019 to 2026Enrolled230ConditionsObsessive-Compulsive Disorder
NCT07570108 nawithdrawnnot on this mapstarted 2026, after this paper: background citation

Precision Functional Mapping to Predict and Track ERP Response in Pediatric Obsessive-Compulsive Disorder: A Longitudinal fMRI Study

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2026 to 2031Enrolled0ConditionsObsessive-Compulsive DisorderArmsExposure and Response Prevention Therapy, Clinical Assessments, Research MRI Sessions
3 · Its place in the literature

Who cites it

318 citing papers in PubMed, 17 syntheses or guidelines pooled it.

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  13. Genetics of OCD and Related Disorders; Searching for Shared Factors.Current topics in behavioral neurosciences · 2021
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  15. Mental health dished up-the use of iPSC models in neuropsychiatric research.Journal of neural transmission (Vienna, Austria : 1996) · 2020
    Pooled it
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  20. Functional neurological disorder, suggestion and virtual reality: neuroanatomical and computational perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
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258 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David L Pauls1] Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115 USA. [2] Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [3] Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Amitai Abramovitch1] Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115 USA. [2] Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Scott L Rauch1] Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115 USA. [2] Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [3] McLean Hospital, Belmont, Massachusetts 02478, USA.
Daniel A Geller1] Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115 USA. [2] Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Funding

A GENETIC LINKAGE STUDY OF GTSR01NS040024 · NINDS · TOURETTE SYNDROME ASSOCIATION, INC · PI PAULS, DAVID L · 2000 to 2004
$9.5M
GENETICS OF TOURETTE SYNDROMER01NS016648 · NINDS · YALE UNIVERSITY · PI PAULS, DAVID L · 1985 to 2009
$9.0M
A Genetic Linkage Study of GTSU01NS040024 · NINDS · TOURETTE ASSOCIATION OF AMERICA, INC. · PI SCHARF, JEREMIAH M · 2007 to 2012
$8.0M
Obsessive-compulsive disorder (OCD) Collaborative Genetics Association StudyR01MH079489 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI GELLER, DANIEL A · 2007 to 2010
$3.4M
NIMH NIH HHS MH079489NINDS NIH HHS NS16648NINDS NIH HHS NS40024
6 · The paper itself

Abstract

Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviours that are experienced as unwanted. Family and twin studies have demonstrated that OCD is a multifactorial familial condition that involves both polygenic and environmental risk factors. Neuroimaging studies have implicated the cortico-striato-thalamo-cortical circuit in the pathophysiology of the disorder, which is supported by the observation of specific neuropsychological impairments in patients with OCD, mainly in executive functions. Genetic studies indicate that genes affecting the serotonergic, dopaminergic and glutamatergic systems, and the interaction between them, play a crucial part in the functioning of this circuit. Environmental factors such as adverse perinatal events, psychological trauma and neurological trauma may modify the expression of risk genes and, hence, trigger the manifestation of obsessive-compulsive behaviours.

Indexed as

NeurobiologyObsessive-Compulsive DisorderBrainDopamineEnvironmentFamily HealthGlutamic AcidHumansRisk FactorsSignal TransductionDopamineGlutamic Acid

Identifiers

PMID24840803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.