ArticleThe Journal of pediatrics2014
Vasopressin improves hemodynamic status in infants with congenital diaphragmatic hernia.
Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Ventricular function in congenital diaphragmatic hernia: a systematic review and meta-analysis.European journal of pediatrics · 2022Pooled it
- Vasopressin versus dopamine for treatment of hypotension in extremely low birth weight infants: a randomized, blinded pilot study.The Journal of pediatrics · 2015Trial
- Oxygenation indices and echocardiographic markers of pulmonary hypertension and ventricular dysfunction in congenital diaphragmatic hernia.BMJ paediatrics open · 2025Article
- A Delicate Balance: Anesthetic Management for Neonatal Congenital Diaphragmatic Hernia Repair.Cureus · 2024Article
- Vasopressin as adjunctive therapy in pulmonary hypertension associated with refractory systemic hypotension in term newborns.Journal of perinatology : official journal of the California Perinatal Association · 2024Observational
- Evaluation of Hyponatremia in Infants on Vasopressin Therapy.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- An Update on Pharmacologic Management of Neonatal Hypotension: When, Why, and Which Medication.Children (Basel, Switzerland) · 2024Review
- The role of point-of-care ultrasound in the management of neonates with congenital diaphragmatic hernia.Pediatric research · 2024Review
- Vasopressin induced hyponatremia in infants <3 months of age in the neonatal intensive care unit.Frontiers in pediatrics · 2024Article
- Hemodynamic management of congenital diaphragmatic hernia: the role of targeted neonatal echocardiography.World journal of pediatric surgery · 2024Review
- Evidence-Based Guidelines for Acute Stabilization and Management of Neonates with Persistent Pulmonary Hypertension of the Newborn.American journal of perinatology · 2023Article
- Early vasopressin infusion improves oxygenation in infants with congenital diaphragmatic hernia.Frontiers in pediatrics · 2023Article
- A new physiologic-based integrated algorithm in the management of neonatal hemodynamic instability.European journal of pediatrics · 2022Review
- Use of vasopressin in persistent pulmonary hypertension of the newborn: A case series.SAGE open medical case reports · 2022Article
- The heart in congenital diaphragmatic hernia: Knowns, unknowns, and future priorities.Frontiers in pediatrics · 2022Review
- Under Pressure: The Pulmonary Vasculature and Its Role in the Pediatric Cardiac ICU.American journal of respiratory and critical care medicine · 2021Article
- Management of systemic hypotension in term infants with persistent pulmonary hypertension of the newborn: an illustrated review.Archives of disease in childhood. Fetal and neonatal edition · 2021Review
- Utility of Low Dose Vasopressin for Persistent Pulmonary Hypertension of Newborn with Catecholamine Refractory Shock.Indian journal of pediatrics · 2021Article
- Treating Hypotension in Preterm Neonates With Vasoactive Medications.Frontiers in pediatrics · 2018Review
- Inotropes for Preterm Infants: 50 Years on Are We Any Wiser?Frontiers in pediatrics · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo assess the ability of vasopressin to stabilize hemodynamics in infants with systemic hypotension secondary to congenital diaphragmatic hernia (CDH). STUDY
designA retrospective chart review was performed to identify 13 patients with CDH treated with vasopressin for refractory hypotension to assess the effect of vasopressin on pulmonary and systemic hemodynamics and gas exchange in this setting. Data collected included demographics, respiratory support, inotropic agents, pulmonary and systemic hemodynamics, urine output, and serum and urine sodium levels during vasopressin therapy.
resultsVasopressin therapy increased mean arterial pressure and decreased pulmonary/systemic pressure ratio, heart rate, and fraction of inspired oxygen. In 6 of 13 patients, extracorporeal membrane oxygenation therapy was no longer indicated after treatment with vasopressin. Improvement in left ventricular function and oxygenation index after vasopressin initiation was associated with a decreased need for extracorporeal membrane oxygenation therapy. Prolonged vasopressin treatment was associated with hyponatremia, increased urine output, and increased urine sodium.
conclusionsVasopressin stabilized systemic hemodynamics without adverse effects on pulmonary hemodynamics in a subset of infants with CDH. Our results suggest a potential role for vasopressin therapy in patients with CDH with catecholamine-resistant refractory hypotension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.