ArticleGenome research2014
The chromatin landscape of Drosophila: comparisons between species, sexes, and chromosomes.
Article in Genome research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 46 citations in OpenAlex.
- Chromatin state dynamics during the Plasmodium falciparum intraerythrocytic development cycle.BMC genomics · 2026Article
- Chromatin Landscape Is Associated With Sex-Biased Expression and Drosophila-Like Dosage Compensation of the Z Chromosome in Artemia franciscana.Molecular biology and evolution · 2025Article
- Interactions between U and V sex chromosomes during the life cycle of Ectocarpus.Development (Cambridge, England) · 2024Article
- Article
- Sex-Biased Expression Is Associated With Chromatin State in Drosophila melanogaster and Drosophila simulans.Molecular biology and evolution · 2023Article
- Sex-biased expression is associated with chromatin state inbioRxiv : the preprint server for biology · 2023Article
- Mode and Tempo of 3D Genome Evolution in Drosophila.Molecular biology and evolution · 2022Article
- Transposable element accumulation drives size differences among polymorphic Y Chromosomes inGenome research · 2022Article
- Chromatin landscape associated with sexual differentiation in a UV sex determination system.Nucleic acids research · 2022Article
- High Stability of the Epigenome in Drosophila Interspecific Hybrids.Genome biology and evolution · 2022Article
- A transposon expression burst accompanies the activation of Y-chromosome fertility genes during Drosophila spermatogenesis.Nature communications · 2021Article
- Epigenetics drive the evolution of sex chromosomes in animals and plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior.PLoS genetics · 2021Article
- The Drosophila Y Chromosome Affects Heterochromatin Integrity Genome-Wide.Molecular biology and evolution · 2020Article
- Genome-wide analysis of H3K4me3 and H3K27me3 modifications due to Lr28 for leaf rust resistance in bread wheat (Triticum aestivum).Plant molecular biology · 2020Article
- Small Segmental Duplications in Drosophila-High Rate of Emergence and Elimination.Genome biology and evolution · 2019Article
- Article
- Sex and the TEs: transposable elements in sexual development and function in animals.Mobile DNA · 2019Review
- Systematic Analysis of SIN3 Histone Modifying Complex Components During Development.Scientific reports · 2018Article
- Sex gap in aging and longevity: can sex chromosomes play a role?Biology of sex differences · 2018Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The chromatin landscape is key for gene regulation, but little is known about how it differs between sexes or between species. Here, we study the sex-specific chromatin landscape of Drosophila miranda, a species with young sex chromosomes, and compare it with Drosophila melanogaster. We analyze six histone modifications in male and female larvae of D. miranda (H3K4me1, H3K4me3, H3K36me3, H4K16ac, H3K27me3, and H3K9me2), and define seven biologically meaningful chromatin states that show different enrichments for transcribed and silent genes, repetitive elements, housekeeping, and tissue-specific genes. The genome-wide distribution of both active and repressive chromatin states differs between males and females. In males, active chromatin is enriched on the X, relative to females, due to dosage compensation of the hemizygous X. Furthermore, a smaller fraction of the euchromatic portion of the genome is in a repressive chromatin state in males relative to females. However, sex-specific chromatin states appear not to explain sex-biased expression of genes. Overall, conservation of chromatin states between male and female D. miranda is comparable to conservation between D. miranda and D. melanogaster, which diverged >30 MY ago. Active chromatin states are more highly conserved across species, while heterochromatin shows very low levels of conservation. Divergence in chromatin profiles contributes to expression divergence between species, with ∼26% of genes in different chromatin states in the two species showing species-specific or species-biased expression, an enrichment of approximately threefold over null expectation. Our data suggest that heteromorphic sex chromosomes in males (that is, a hypertranscribed X and an inactivated Y) may contribute to global redistribution of active and repressive chromatin marks between chromosomes and sexes.
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