ArticleThe Biochemical journal2014
Fibrin binds to collagen and provides a bridge for αVβ3 integrin-dependent contraction of collagen gels.
Article in The Biochemical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Structure-functionality relationship of collagen-fibrin interpenetrating hydrogels for engineered tumor-stroma models.Acta biomaterialia · 2026Article
- Matrix influence of collagen: fibrin interpenetrating hydrogels on microvascular networks and osteogenesis.Biomaterials advances · 2026Article
- Material-dependent effects of injectable platelet rich-fibrin on growth factor release, inflammation, and osteoclast activity: an in vitro study.BMC oral health · 2026Article
- Fibrinogen in extracellular matrix remodeling: functional switching, source heterogeneity, and biomaterial translation.Frontiers in cell and developmental biology · 2026Review
- Visualizing dynamics of membrane rafts on live cells.Science advances · 2025Article
- Rapid Biofabrication of an Advanced Microphysiological System Mimicking Phenotypical Heterogeneity and Drug Resistance in Glioblastoma.Advanced healthcare materials · 2024Article
- The role of periostin in cardiac fibrosis.Heart failure reviews · 2024Review
- Fibrin gel enhanced trilayer structure in cell-cultured constructs.Biotechnology and bioengineering · 2023Article
- Effect of niche components on masseter satellite cell differentiation on fibrin coatings.European journal of oral sciences · 2022Article
- Oxygen, pH, Lactate, and Metabolism-How Old Knowledge and New Insights Might Be Combined for New Wound Treatment.Medicina (Kaunas, Lithuania) · 2021Review
- Decellularized Disc Hydrogels for hBMSCs tissue-specific differentiation and tissue regeneration.Bioactive materials · 2021Article
- Intra-Operative Bioprinting of Hard, Soft, and Hard/Soft Composite Tissues for Craniomaxillofacial Reconstruction.Advanced functional materials · 2021Article
- Type I Collagen-Fibrin Mixed Hydrogels: Preparation, Properties and Biomedical Applications.Gels (Basel, Switzerland) · 2020Review
- Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.The Journal of cell biology · 2019Article
- The tumor cell-secreted matricellular protein WISP1 drives pro-metastatic collagen linearization.The EMBO journal · 2019Article
- Skin Acute Wound Healing: A Comprehensive Review.International journal of inflammation · 2019Review
- Incorporation of Collagen and Hyaluronic Acid to Enhance the Bioactivity of Fibrin-Based Hydrogels for Nucleus Pulposus Regeneration.Journal of functional biomaterials · 2018Article
- Integrin αExperimental physiology · 2018Article
- Compression-induced structural and mechanical changes of fibrin-collagen composites.Matrix biology : journal of the International Society for Matrix Biology · 2017Article
- Human Umbilical Cord Wharton Jelly-Derived Adult Mesenchymal Stem Cells, in Biohybrid Scaffolds, for Experimental Skin Regeneration.Stem cells international · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The functional significance of fibrin deposits typically seen in inflammatory lesions, carcinomas and in healing wounds is not fully understood. In the present study, we demonstrate that fibrinogen/fibrin specifically bound to native Col I (collagen type I) and used the Col I fibre network as a base to provide a functional interface matrix that connects cells to the Col I fibres through αVβ3 integrins. This allowed murine myoblast C2C12 cells to contract the collagenous composite gel via αVβ3 integrin. We show that fibrinogen specifically bound to immobilized native Col I at the site known to bind matrix metalloproteinase-1, discoidin domain receptor-2 and fibronectin, and that binding had no effect on Col I fibrillation. A specific competitive inhibitor blocking the Col-I-binding site for fibrinogen abolished the organization of fibrin into discernable fibrils, as well as the C2C12-mediated contraction of Col I gels. Our data show that fibrin can function as a linkage protein between Col I fibres and cells, and suggest that fibrin at inflammatory sites indirectly connects αVβ3 integrins to Col I fibres and thereby promotes cell-mediated contraction of collagenous tissue structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.