ArticleSurgery today2014
Obesity was associated with a decreased postoperative recurrence of rectal cancer in a Japanese population.
Article in Surgery today, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Evaluating the influence of the obesity paradox on survival outcomes in patients being treated surgically for rectal cancer-a systematic review and meta-analysis.International journal of colorectal disease · 2025Pooled it
- Article
- Risk factors for local recurrence in patients with clinical stage II/III low rectal cancer: A multicenter retrospective cohort study in Japan.Annals of gastroenterological surgery · 2025Article
- Prognostic value of mesorectal package area in patients with locally advanced rectal cancer following neoadjuvant chemoradiotherapy: A retrospective cohort study.Frontiers in oncology · 2022Article
- Quantitative assessment of mesorectal fat: new prognostic biomarker in patients with mid-to-lower rectal cancer.European radiology · 2019Article
- Oncologic evaluation of obesity as a factor in patients with rectal cancer undergoing laparoscopic surgery: a propensity-matched analysis using body mass index.Annals of surgical treatment and research · 2019Article
- Overweight but not obesity is associated with decreased survival in rectal cancer.Contemporary oncology (Poznan, Poland) · 2018Article
- Article
- Association between obesity and local control of advanced rectal cancer after combined surgery and radiotherapy.Radiation oncology journal · 2016Article
- Effects of laparoscopic surgery on the patterns of death in elderly colorectal cancer patients: competing risk analysis compared with open surgery.Surgery today · 2016Article
- Effects of body mass index (BMI) on surgical outcomes: a nationwide survey using a Japanese web-based database.Surgery today · 2015Article
- Effect of particle beam radiotherapy on locally recurrent rectal cancer: Three case reports.Molecular and clinical oncology · 2015Article
- Obesity and cancer: at the crossroads of cellular metabolism and proliferation.Surgery for obesity and related diseases : official journal of the American Society for Bariatric SurgeryReview
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeObesity contributes to the technical difficulty of rectal surgery and is considered to be a risk factor for postoperative complications. The impact of obesity on the long-term outcomes of rectal cancer surgery remains unclear.
methodsA total of 263 consecutive rectal cancer patients who underwent surgery were categorized into two groups according to the body mass index (BMI) based on the Asian BMI classification: non-obese (BMI <25 kg/m(2)) and obese (BMI ≥25 kg/m(2)). The postoperative survival and recurrence rates and oncological surgical quality indicators were compared between groups using the univariate and multivariate analyses. The differences in recurrence patterns were assessed by a competing risk regression analysis.
results64 (24%) patients were included in the obese group. The number of retrieved lymph nodes was significantly greater in the non-obese group than in the obese group (22.4 vs. 16.0, P < 0.01). The 5-year disease-free survival (DFS) rates were 86.5 and 68.8% in the obese and non-obese groups, respectively (P = 0.01). The multivariate analysis demonstrated that obesity significantly decreased the postoperative recurrence rate (P = 0.04). Moreover, the BMI was significantly associated with distant metastasis (P = 0.04).
conclusionsObese rectal cancer patients have high DFS rates and a decreased incidence of distant metastases compared to non-obese patients. The BMI may be a key factor for predicting the postoperative prognosis and determination of an appropriate strategy for the treatment of rectal cancer patients.
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