ReviewNature reviews. Cardiology2014
Strategies to improve cardiac resynchronization therapy.
Review in Nature reviews. Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparative effects of biventricular and right ventricular pacing on clinical outcomes in atrioventricular block: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Image-guided left ventricular lead placement in cardiac resynchronization therapy for patients with heart failure: a meta-analysis.BMC cardiovascular disorders · 2015Pooled it
- Differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapy.ESC heart failure · 2020Trial
- Computational Modelling of Selective Capture Mechanisms in Conduction System Pacing.Annals of biomedical engineering · 2026Article
- Left bundle branch vs biventricular pacing: mechanistic insights from a canine model.European heart journal · 2026Article
- Resynchronisation efficacy of pacing strategies depends on the assessment metric: a computational study.Frontiers in physiology · 2026Article
- Is Left Bundle Branch Pacing Feasible in Patients With Ventricular Septal Defect?Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Article
- Cardiovascular imaging in children with cardiac implantable electronic devices.Pediatric radiology · 2025Review
- Left Ventricular Endocardial Pacing Therapy Guided by 3D Mapping for Conventional Cardiac Resynchronization Therapy Non-Response or Face Challenges.Acta Cardiologica Sinica · 2025Article
- Heart Failure and Wide QRS: Clinical and Pharmacological Perspectives.Biomedicines · 2025Review
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
- Impact of myocardial phenotype on optimal atrioventricular delay settings during biventricular and left bundle branch pacing at rest and during exercise: insights from a virtual patient study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- The Atrioventricular Coupling in Heart Failure: Pathophysiological and Therapeutic Aspects.Reviews in cardiovascular medicine · 2024Review
- Article
- Cardiac CT in CRT as a Singular Imaging Modality for Diagnosis and Patient-Tailored Management.Journal of clinical medicine · 2023Review
- Electrocardiogram-based deep learning improves outcome prediction following cardiac resynchronization therapy.European heart journal · 2023Article
- Safety and efficacy of His-Purkinje system pacing in the treatment of patients with atrial fibrillation and heart failure: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Does mechanical dyssynchrony in addition to QRS area ensure sustained response to cardiac resynchronization therapy?European heart journal. Cardiovascular Imaging · 2022Article
- Prediction of Cardiac Resynchronization Therapy Response Using a Lead Placement Score Derived From 4-Dimensional Computed Tomography.Circulation. Cardiovascular imaging · 2022Article
- Four-dimensional computed tomography of the left ventricle, Part I: Motion artifact reduction.Medical physics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac resynchronization therapy (CRT) emerged 2 decades ago as a useful form of device therapy for heart failure associated with abnormal ventricular conduction, indicated by a wide QRS complex. In this Review, we present insights into how to achieve the greatest benefits with this pacemaker therapy. Outcomes from CRT can be improved by appropriate patient selection, careful positioning of right and left ventricular pacing electrodes, and optimal timing of electrode stimulation. Left bundle branch block (LBBB), which can be detected on an electrocardiogram, is the predominant substrate for CRT, and patients with this conduction abnormality yield the most benefit. However, other features, such as QRS morphology, mechanical dyssynchrony, myocardial scarring, and the aetiology of heart failure, might also determine the benefit of CRT. No single left ventricular pacing site suits all patients, but a late-activated site, during either the intrinsic LBBB rhythm or right ventricular pacing, should be selected. Positioning the lead inside a scarred region substantially impairs outcomes. Optimization of stimulation intervals improves cardiac pump function in the short term, but CRT procedures must become easier and more reliable, perhaps with the use of electrocardiographic measures, to improve long-term outcomes.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.