Hypertension: How should data from SYMPLICITY HTN-3 be interpreted?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed.

1. Renal denervation for hypertension.Nature reviews. Cardiology · 2025
   Review
2. Acupuncture Attenuates Renal Sympathetic Activity and Blood Pressure via Beta-Adrenergic Receptors in Spontaneously Hypertensive Rats.Neural plasticity · 2017
   Article
3. Renal Denervation for Treatment of Hypertension: a Second Start and New Challenges.Current hypertension reports · 2016
   Review
4. Managing Treatment-Resistant Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2015
   Review
5. Beyond blood pressure: percutaneous renal denervation for the management of sympathetic hyperactivity and associated disease states.Journal of the American Heart Association · 2015
   Review
6. Renal denervation for severe hypertension in a small child with Turner syndrome: miniaturisation of the procedure and results.BMJ case reports · 2015
   Article
7. Renal sympathetic denervation after Symplicity HTN-3 and therapeutic drug monitoring in severe hypertension.Frontiers in physiology · 2015
   Review
8. Renal Denervation After Symplicity HTN-3 - Back to Basics. Review of the Evidence.European cardiology · 2014
   Review
9. Where and when device therapy may be useful in the management of drug-resistant hypertension.Current cardiology reports · 2014
   Review
10. Ethnicity and sympathetic tone: predictors of the blood pressure response to renal denervation?Nature reviews. Cardiology · 2014
    Article
11. Renal denervation--a valid treatment option despite SYMPLICITY HTN-3.Nature reviews. Cardiology · 2014
    Article

Corrections and comments

• Commented on by
  Renal denervation--a valid treatment option despite SYMPLICITY HTN-3.2014
• Commented on by
  Ethnicity and sympathetic tone: predictors of the blood pressure response to renal denervation?2014

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as