ArticleJournal of toxicology and environmental health. Part A2014
Particulate matter from Saudi Arabia induces genes involved in inflammation, metabolic syndrome and atherosclerosis.
Article in Journal of toxicology and environmental health. Part A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Internal exposure levels of polycyclic aromatic hydrocarbons in children and adolescents: a systematic review and meta-analysis.Environmental health and preventive medicine · 2019Pooled it
- Environmental mixtures and body mass index in two prospective US-based cohorts of female nurses.Journal of hazardous materials · 2024Article
- Synergistic or Antagonistic Health Effects of Long- and Short-Term Exposure to Ambient NOInternational journal of environmental research and public health · 2022Review
- Traffic-related air pollution, biomarkers of metabolic dysfunction, oxidative stress, and CC16 in children.Journal of exposure science & environmental epidemiology · 2022Article
- Systematic Review of Exposure to Polycyclic Aromatic Hydrocarbons and Obstructive Lung Disease.Journal of health & pollution · 2021Review
- Particulate matter inhalation and the exacerbation of cardiopulmonary toxicity due to metabolic disease.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Exposure to fine particulate matter induces self-recovery and susceptibility of oxidative stress and inflammation in rat lungs.Environmental science and pollution research international · 2020Article
- Association of Long-term Exposure to Ambient Air Pollutants With Risk Factors for Cardiovascular Disease in China.JAMA network open · 2019Article
- Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary Effects.Toxics · 2019Review
- Association between Exposure to Ambient Air Particulates and Metabolic Syndrome Components in a Saudi Arabian Population.International journal of environmental research and public health · 2017Article
- Evaluation of the Effects of Airborne Particulate Matter on Bone Marrow-Mesenchymal Stem Cells (BM-MSCs): Cellular, Molecular and Systems Biological Approaches.International journal of environmental research and public health · 2017Article
- Particulate matter and atherosclerosis: a bibliometric analysis of original research articles published in 1973-2014.BMC public health · 2016Review
- A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes.Environmental health : a global access science source · 2016Article
- Association between sleeping hours and cardiometabolic risk factors for metabolic syndrome in a Saudi Arabian population.BMJ open · 2015Article
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- In Vivo Exposures to Particulate Matter Collected from Saudi Arabia or Nickel Chloride Display Similar Dysregulation of Metabolic Syndrome Genes.Journal of toxicology and environmental health. Part A · 2015Article
- Evaluation of the Pulmonary Toxicity of Ambient Particulate Matter From Camp Victory, Iraq.Journal of toxicology and environmental health. Part A · 2015Article
- 2022 Saudi Guidelines for the Management of Dyslipidemia.Heart views : the official journal of the Gulf Heart AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Airborne particulate matter (PM) exposure is a major environmental health concern and is linked to metabolic disorders, such as cardiovascular diseases (CVD) and diabetes, which are on the rise in the Kingdom of Saudi Arabia. This study investigated changes in mouse lung gene expression produced by administration of PM10 collected from Jeddah, Saudi Arabia. FVB/N mice were exposed to 100 μg PM10 or water by aspiration and euthanized 24 h later. The bronchoalveolar lavage fluid (BALF) was collected and analyzed for neutrophil concentration and tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels. RNA was extracted from lungs and whole transcript was analyzed using Affymetrix Mouse Gene 1.0 ST Array. Mice exposed to PM10 displayed an increase in neutrophil concentration and elevated TNF-α and IL-6 levels. Gene expression analysis revealed that mice exposed to PM10 displayed 202 genes that were significantly upregulated and 40 genes that were significantly downregulated. PM10 induced genes involved in inflammation, cholesterol and lipid metabolism, and atherosclerosis. This is the first study to demonstrate that Saudi Arabia PM10 increases in vivo expression of genes located in pathways associated with diseases involving metabolic syndrome and atherosclerosis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.