Evidence map›Paper›PMID 24839881›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2014

Manic symptoms in youth: dimensions, latent classes, and associations with parental psychopathology.

Pedro Mario Pan, Giovanni Abrahão Salum, Ary Gadelha, Tais Moriyama, Hugo Cogo-Moreira, Ana Soledade Graeff-Martins, Maria Conceição Rosario, Guilherme Vanoni Polanczyk, Elisa Brietzke, Luis Augusto Rohde and 4 more

Abstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Suicidal Behavior in Adolescents: A Latent Class Analysis.International journal of environmental research and public health · 2020
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Pedro Mario PanFederal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil. Electronic address: pedro.pan@unifesp.br.
Giovanni Abrahão SalumINCT-CNPq and Federal University of Rio Grande do Sul, Brazil.
Ary GadelhaFederal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil.
Tais MoriyamaFederal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil.
Hugo Cogo-MoreiraFederal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil.
Ana Soledade Graeff-MartinsINCT-CNPq and University of São Paulo, Brazil.
Maria Conceição RosarioFederal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil.
Guilherme Vanoni PolanczykINCT-CNPq and University of São Paulo, Brazil.
Elisa BrietzkeFederal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil.
Luis Augusto RohdeINCT-CNPq and Federal University of Rio Grande do Sul, Brazil.
Argyris StringarisKing's College London, UK.
Robert GoodmanKing's College London, UK.
Ellen LeibenluftNational Institute of Mental Health (NIMH), USA.
Rodrigo Affonseca BressanFederal University of São Paulo and the National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq), Brazil.
Universidade Federal de São Paulo · BRNational Council for Scientific and Technological Development · BRKing's College London · GBUniversidade Federal do Rio Grande do Sul · BRNational Institute of Mental Health · USUniversidade de São Paulo · BR

Funding

The Pathophysiology and Treatment Of Children With Severe Mood DysregulationZIAMH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2023
$34.0M
The Phenomenology And Neurophysiology Of Juvenile Bipolar DisorderZIAMH002778 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2017
$10.8M
The Phenomenology And Neurophysiology Of Juvenile Bipolar DisorderZ01MH002778 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2000 to 2008
$3.1M
Intramural NIH HHS Z01 MH002778Wellcome Trust
6 · The paper itself

Abstract

objectiveThe purpose of the study was to define the latent structure of parent-reported manic symptoms and their association with functional impairment and familial risk in a community sample of Brazilian children.

methodWe screened for manic symptoms in a community sample of 2,512 children 6 to 12 years of age. Parents of children with "episodes of going abnormally high" completed a detailed mania section (n = 479; 19.1%). Confirmatory factor analysis (CFA) tested a solution with "Under-Control (UC)" and "Exuberant (EX)" dimensions, investigating the severity (threshold) and factor loading of each symptom. We also used latent class analysis (LCA) to evaluate the latent categorical structure of manic symptoms. Associations of these latent constructs with psychiatric comorbidity, psychosocial impairment, and family history of psychopathology were tested.

resultsThe 2-dimensional model fit the data well. Only the UC dimension was associated with psychiatric morbidity, psychosocial impairment, and a family history of mania, depression, or suicide attempts. Both UC and EX items discriminated subjects with "episodes of going abnormally high," but EX items lay at the mild end of the severity spectrum, whereas UC items lay at the severe end. The LCA yielded a small group of children with high levels of manic symptoms and a distinct profile of psychiatric comorbidity and impairment ("high-symptom group").

conclusionIn a large, community-based sample, we found a 2-dimensional latent structure for parent-reported manic symptoms in youth, and demonstrated familial associations between the UC dimension and affective disorders. Both UC and EX items are clinically useful, but their contributions vary with symptom severity.

Indexed as

FamilyBipolar DisorderBrazilChildComorbidityFemaleHumansMaleMental DisordersSeverity of Illness Indexbipolarfactor analysisfamily historylatentmania

Identifiers

PMID24839881
PMCPMC4477846
OpenAlexW1977577199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.