ArticleChemical science2014
Total syntheses of indolactam alkaloids (-)-indolactam V, (-)-pendolmycin, (-)-lyngbyatoxin A, and (-)-teleocidin A-2.
Article in Chemical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Higher-Level Strategies for Computer-Aided Retrosynthesis.ACS central science · 2026Article
- The Chemistry of Phytoplankton.Chemical reviews · 2024Review
- Evaluation of Retro-Aldol vs Retro-Carbonyl-Ene Mechanistic Pathways in a Complexity-Generating C-C Bond Fragmentation.Organic letters · 2024Article
- Total Synthesis of Phenanthroindolizidines Using Strained Azacyclic Alkynes.Organic letters · 2023Article
- Indolactam Dipeptides as Nanomolar Gli Inhibitors.ACS medicinal chemistry letters · 2022Article
- Regioselective molybdenum-catalyzed allylic substitution of tertiary allylic electrophiles: methodology development and applications.Chemical science · 2020Article
- Safety Assessment of Benzyne Generation from a Silyl Triflate Precursor.Organic letters · 2020Article
- 11-Step Total Synthesis of Teleocidins B-1-B-4.Journal of the American Chemical Society · 2019Article
- Expanding the Strained Alkyne Toolbox: Generation and Utility of Oxygen-Containing Strained Alkynes.Journal of the American Chemical Society · 2016Article
- Computational predictions of substituted benzyne and indolyne regioselectivities.Tetrahedron letters · 2015Article
- C7-derivatization of C3-alkylindoles including tryptophans and tryptamines.The Journal of organic chemistry · 2014Article
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Authors and funding
4 authors.
Funding
Abstract
We report the total syntheses of (-)-indolactam V and the C7-substituted indolactam alkaloids (-)-pendolmycin, (-)-lyngbyatoxin A, and (-)-teleocidin A-2. The strategy for preparing indolactam V relies on a distortion-controlled indolyne functionalization reaction to establish the C4-N linkage, in addition to an intramolecular conjugate addition to build the conformationally-flexible nine-membered ring. The total synthesis of indolactam V then sets the stage for the divergent synthesis of the other targeted alkaloids. Specifically, late-stage sp
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