ArticleChemical physics2013
Real-time tracking of CO migration and binding in the α and β subunits of human hemoglobin via 150-ps time-resolved Laue crystallography.
Article in Chemical physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A Bright and Dynamic Future in Structural Biology.Advances in experimental medicine and biology · 2026Review
- Direct observation of two-channel photodissociation of carbon monoxide from the hemoglobin subunits.Nature communications · 2025Article
- Kinetic mechanisms for OMolecular aspects of medicine · 2022Review
- Time-resolved X-ray scattering studies of proteins.Current opinion in structural biology · 2021Review
- Towards understanding non-equivalence of α and β subunits within human hemoglobin in conformational relaxation and molecular oxygen rebinding.Chemical science · 2021Article
- High-resolution macromolecular crystallography at the FemtoMAX beamline with time-over-threshold photon detection.Journal of synchrotron radiation · 2021Article
- Direct observation of ligand migration within human hemoglobin at work.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Melting of Hemoglobin in Native Solutions as measured by IMS-MS.Analytical chemistry · 2020Article
- Interaction of human hemoglobin and semi-hemoglobins with the Staphylococcus aureus hemophore IsdB: a kinetic and mechanistic insight.Scientific reports · 2019Article
- Watching Proteins Function with Time-resolved X-ray Crystallography.Journal of physics D: Applied physics · 2017Article
- Picosecond Photobiology: Watching a Signaling Protein Function in Real Time via Time-Resolved Small- and Wide-Angle X-ray Scattering.Journal of the American Chemical Society · 2016Article
- Serial femtosecond crystallography opens new avenues for Structural Biology.Protein and peptide letters · 2016Article
- Sub-100-ps structural dynamics of horse heart myoglobin probed by time-resolved X-ray solution scattering.Chemical physics · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We have developed the method of picosecond Laue crystallography and used this capability to probe ligand dynamics in tetrameric R-state hemoglobin (Hb). Time-resolved, 2 Å-resolution electron density maps of photolyzed HbCO reveal the time-dependent population of CO in the binding (A) and primary docking (B) sites of both α and β subunits from 100 ps to 10 μs. The proximity of the B site in the β subunit is about 0.25 Å closer to its A binding site, and its
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Registered trials
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