ReviewBulletin of the World Health Organization2014
Prevention and control of neglected tropical diseases: overview of randomized trials, systematic reviews and meta-analyses.
Review in Bulletin of the World Health Organization, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Effectiveness of vector control methods for the control of cutaneous and visceral leishmaniasis: A meta-review.PLoS neglected tropical diseases · 2021Pooled it
- Efficacy and safety of praziquantel and dihydroartemisinin piperaquine combination for treatment and control of intestinal schistosomiasis: A randomized, non-inferiority clinical trial.PLoS neglected tropical diseases · 2020Trial
- Antibiotic resistance and virulence of bacteria in spices: a systematic review.One health outlook · 2025Review
- Review
- Detection of Tropical Diseases Caused by Mosquitoes Using CRISPR-Based Biosensors.Tropical medicine and infectious disease · 2022Review
- Article
- Interventions for ulceration and other skin changes caused by nerve damage in leprosy.The Cochrane database of systematic reviews · 2019Review
- Emerging Resistance of Neglected Tropical Diseases: A Scoping Review of the Literature.International journal of environmental research and public health · 2019Article
- A bibliometric analysis of human strongyloidiasis research (1968 to 2017).Tropical diseases, travel medicine and vaccines · 2019Article
- International Clinical Trials in Latin American and Caribbean Countries: Research and Development to Meet Local Health Needs.Frontiers in pharmacology · 2017Article
- Emerging and Neglected Infectious Diseases: Insights, Advances, and Challenges.BioMed research international · 2017Review
- Spatio-temporal correlation networks of dengue in the state of Bahia.BMC public health · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo analyse evidence from randomized controlled trials (RCTs) on the prevention and control of neglected tropical diseases (NTDs) and to identify areas where evidence is lacking.
methodsThe Cochrane Central Register of Controlled Trials and PubMed were searched for RCTs and the Cochrane Database of Systematic Reviews and PubMed were searched for meta-analyses and systematic reviews, both from inception to 31 December 2012.
findingsOverall, 258 RCTs were found on American trypanosomiasis, Buruli ulcer, dengue, geohelminth infection, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis or trachoma. No RCTs were found on cysticercosis, dracunculiasis, echinococcosis, foodborne trematodes, or human African trypanosomiasis. The most studied diseases were geohelminth infection (51 RCTs) and leishmaniasis (46 RCTs). Vaccines, chemoprophylaxis and interventions targeting insect vectors were evaluated in 113, 99 and 39 RCTs, respectively. Few addressed how best to deliver preventive chemotherapy, such as the choice of dosing interval (10) or target population (4), the population coverage needed to reduce transmission (2) or the method of drug distribution (1). Thirty-one publications containing 32 systematic reviews (16 with and 16 without meta-analyses) were found on American trypanosomiasis, dengue, geohelminths, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, schistosomiasis or trachoma. Together, they included only 79 of the 258 published RCTs (30.6%). Of 36 interventions assessed, 8 were judged effective in more than one review.
conclusionFew RCTs on the prevention or control of the principal NTDs were found. Trials on how best to deliver preventive chemotherapy were particularly rare.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.