Evidence map›Paper›PMID 24839253›Full record

ReviewHepatology (Baltimore, Md.)2014

Epidemiology of hepatocellular carcinoma in the United States: where are we? Where do we go?

Hashem B El-Serag, Fasiha Kanwal

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Hepatology (Baltimore, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 339 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
339citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06007846 phase2 / phase3recruitingnot on this mapstarted 2023, after this paper: background citation

A Prospective Cohort Study of Single Agent Memantine in Patients With Child-Pugh Score ≥ B7 Cirrhosis and Hepatocellular Carcinoma

TypeinterventionalSponsorInova Health Care ServicesRan2023 to 2026Enrolled12ConditionsHepatocellular Carcinoma, CirrhosisArmsNamenda
NCT06789757 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

An Open Label Phase II Study of Atezolizumab, Bevacizumab and Memantine in Patients With Hepatocellular Carcinoma

TypeinterventionalSponsorInova Health Care ServicesRan2025 to 2028Enrolled19ConditionsHepatocellular CarcinomaArmsMemantine Hydrochloride, Bevacizumab, Atezolizumab
3 · Its place in the literature

Who cites it

339 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  20. Hepatocellular Carcinoma: A Comprehensive Review.Diseases (Basel, Switzerland) · 2025
    Review

279 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Hashem B El-SeragSection of Gastroenterology and Hepatology, Michael E. DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX; Houston VA HSR&D Center of Excellence Houston, TX.
Fasiha Kanwal

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
Epidemiology and Outcomes of Digestive and Liver Diseases: A Mentoring ProgramK24DK078154 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI EL-SERAG, HASHEM B · 2007 to 2016
$1.1M
Surveillance for Hepatocellular Carcinoma among HCV-infected VeteransR01CA125487 · NCI · BAYLOR COLLEGE OF MEDICINE · PI EL-SERAG, HASHEM B · 2007 to 2009
$875k
12TH CONFERENCE ON HEMOGLOBIN SWITCHINGR13DK058338 · NIDDK · UNIVERSITY OF WASHINGTON · PI STAMATOYANNOPOULOS, GEORGE · 2000 to 2000
$45k
NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA125487NIDDK NIH HHS DK58338NIDDK NIH HHS K24 DK078154NIDDK NIH HHS P30 DK056338PHS HHS K24-04-107
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carcinoma, HepatocellularHumansLiver NeoplasmsRisk FactorsUnited States

Identifiers

PMID24839253
PMCPMC4211957

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.