Evidence map›Paper›PMID 24839145›Full record

Trial reportAmerican journal of perinatology2015

Does maternal body mass index influence treatment effect in women with mild gestational diabetes?

Brian M Casey, Lisa Mele, Mark B Landon, Catherine Y Spong, Susan M Ramin, Ronald J Wapner, Michael W Varner, Dwight J Rouse, John M Thorp, Patrick Catalano and 5 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of perinatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00069576 (A Randomized Clinical Trial of Treatment for Mild Gestational Diabetes Mellitus), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00069576 nacompletednot on this map

A Randomized Clinical Trial of Treatment for Mild Gestational Diabetes Mellitus

TypeinterventionalSponsorThe George Washington University Biostatistics CenterRan2002 to 2013Enrolled7,381ConditionsDiabetes, GestationalArmsnutritional counseling, self blood glucose monitoring
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. The new gestational diabetes: Treatment, evidence and consent.The Australian & New Zealand journal of obstetrics & gynaecology · 2020
    Article
  6. Observational
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 14 institutions in 1 country.

Brian M CaseyDepartment of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas.
Lisa MeleThe George Washington University Biostatistics Center, Washington, District of Columbia.
Mark B LandonDepartment of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio.
Catherine Y Spong
Susan M RaminDepartment of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, Houston, Texas.
Ronald J WapnerDepartment of Obstetrics and Gynecology, Columbia University, New York, New York.
Michael W VarnerDepartment of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah.
Dwight J RouseDepartment of Obstetrics and Gynecology, University of Alabama, Birmingham, Alabama.
John M ThorpDepartment of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.
Patrick CatalanoDepartment of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio.
Margaret HarperDepartment of Obstetrics and Gynecology, Wake Forest University Health Sciences, Winston-Salem, North Carolina.
George SaadeDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas.
Yoram SorokinDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan.
Alan M PeacemanDepartment of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Case Western Reserve University · USColumbia University · USGeorge Washington University · USNational Institutes of Health · USNorthwestern University · USThe Ohio State University · USThe University of Texas Health Science Center at Houston · USThe University of Texas Medical Branch at Galveston · USThe University of Texas Southwestern Medical Center · USUniversity of Alabama at Birmingham · USUniversity of North Carolina at Chapel Hill · USUniversity of Utah · USWake Forest University · USWayne State University · US

Funding

Data Coord Ctr-NICHD Cooperative Multicenter Maternal Medicine Units Research NetU10HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI CLIFTON, REBECCA GERSNOVIEZ · 2009 to 2021
$174.2M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
SARS-CoV-2 Vaccine Pregnancy RegistryU24HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI Rebecca Gersnoviez Clifton · 2021 to 2026
$39.2M
MATERNAL FETAL RESEARCH NETWORK: DATA COORDINATING CTRU01HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI THOM, ELIZABETH ANN · 1998 to 2008
$27.0M
YOGA, IMMUNE FUNCTION, AND HEALTHM01RR000034 · NCRR · OHIO STATE UNIVERSITY · PI PESAVENTO, TODD · 1985 to 2008
$22.7M
The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
Zosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DAVIS, PAMELA B · 1985 to 2007
$22.2M
University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1: BPCAUL1RR025764 · NCRR · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2008 to 2011
$19.4M
NICHD Maternal Fetal Medicine Units NetworkU10HD034116 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI CASEY, BRIAN M · 1996 to 2015
$19.3M
NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR001067NCATS NIH HHS UL1 TR001070NCRR NIH HHS C06 RR011234NCRR NIH HHS M01 RR000034NCRR NIH HHS M01 RR000080NCRR NIH HHS M01-RR00034NCRR NIH HHS M01-RR00080NCRR NIH HHS UL1 RR024989NCRR NIH HHS UL1-RR024989NCRR NIH HHS UL1 RR025764NCRR NIH HHS UL1-RR025764NICHD NIH HHS HD21410NICHD NIH HHS HD27860NICHD NIH HHS HD27869NICHD NIH HHS HD27915NICHD NIH HHS HD27917NICHD NIH HHS HD34116NICHD NIH HHS HD34136NICHD NIH HHS HD34208NICHD NIH HHS HD36801NICHD NIH HHS HD40485NICHD NIH HHS HD40512NICHD NIH HHS HD40544NICHD NIH HHS HD40545NICHD NIH HHS HD40560NICHD NIH HHS HD53097NICHD NIH HHS HD53118NICHD NIH HHS P2C HD050924NICHD NIH HHS U01 HD036801NICHD NIH HHS U10 HD021410NICHD NIH HHS U10 HD027860NICHD NIH HHS U10 HD027869NICHD NIH HHS U10 HD027915NICHD NIH HHS U10 HD027917NICHD NIH HHS U10 HD034116NICHD NIH HHS U10 HD034136NICHD NIH HHS U10 HD034208NICHD NIH HHS U10 HD036801NICHD NIH HHS U10 HD040485NICHD NIH HHS U10 HD040500NICHD NIH HHS U10 HD040512NICHD NIH HHS U10 HD040544NICHD NIH HHS U10 HD040545NICHD NIH HHS U10 HD040560NICHD NIH HHS U10 HD053097NICHD NIH HHS U10 HD053118NICHD NIH HHS U24 HD036801NICHD NIH HHS UG1 HD027869NICHD NIH HHS UG1 HD027915NICHD NIH HHS UG1 HD034116NICHD NIH HHS UG1 HD034208NICHD NIH HHS UG1 HD040485NICHD NIH HHS UG1 HD040500NICHD NIH HHS UG1 HD040512NICHD NIH HHS UG1 HD040544NICHD NIH HHS UG1 HD040545NICHD NIH HHS UG1 HD040560NICHD NIH HHS UG1 HD053097NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

objectiveThe aim of the article is to determine whether maternal body mass index (BMI) influences the beneficial effects of diabetes treatment in women with gestational diabetes mellitus (GDM). STUDY

designSecondary analysis of a multicenter randomized treatment trial of women with GDM. Outcomes of interest were elevated umbilical cord c-peptide levels (> 90th percentile 1.77 ng/mL), large for gestational age (LGA) birth weight (> 90th percentile), and neonatal fat mass (g). Women were grouped into five BMI categories adapted from the World Health Organization International Classification of normal, overweight, and obese adults. Outcomes were analyzed according to treatment group assignment.

resultsA total of 958 women were enrolled (485 treated and 473 controls). Maternal BMI at enrollment was not related to umbilical cord c-peptide levels. However, treatment of women in the overweight, Class I, and Class II obese categories was associated with a reduction in both LGA birth weight and neonatal fat mass. Neither measure of excess fetal growth was reduced with treatment in normal weight (BMI < 25 kg/m(2)) or Class III (BMI ≥ 40 kg/m(2)) obese women.

conclusionThere was a beneficial effect of treatment on fetal growth in women with mild GDM who were overweight or Class I and Class II obese. These effects were not apparent for normal weight and very obese women.

Indexed as

Diet TherapyObesityPregnancy ComplicationsAdipose TissueAdultBlood Glucose Self-MonitoringBody Mass IndexC-PeptideDiabetes, GestationalFemaleFetal BloodFetal MacrosomiaHumansHypoglycemic AgentsInsulinOverweightC-PeptideHypoglycemic AgentsInsulin

Identifiers

PMID24839145
PMCPMC4314711
OpenAlexW2065350106

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.