Evidence map›Paper›PMID 24839065›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2014

Stereoelectronic basis for the kinetic resolution of N-heterocycles with chiral acylating reagents.

Sheng-Ying Hsieh, Benedikt Wanner, Philip Wheeler, André M Beauchemin, Tomislav Rovis, Jeffrey W Bode

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sheng-Ying HsiehLaboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 1-5, 8093 Zürich (Switzerland), Fax: (+41) 44-633-1235.
Benedikt Wanner
Philip Wheeler
André M Beauchemin
Tomislav Rovis
Jeffrey W Bode

Funding

Asymmetric Umpolung Aldehyde Reactions - Supplement to support Alberto MunozR01GM072586 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ROVIS, TOMISLAV · 2005 to 2017
$3.3M
NIGMS NIH HHS GM72586NIGMS NIH HHS R01 GM072586
6 · The paper itself

Abstract

The kinetic resolution of N-heterocycles with chiral acylating agents reveals a previously unrecognized stereoelectronic effect in amine acylation. Combined with a new achiral hydroxamate, this effect makes possible the resolution of various N-heterocycles by using easily prepared reagents. A transition-state model to rationalize the stereochemical outcome of this kinetic resolution is also proposed.

Indexed as

AcylationStereoisomerismCatalysisKineticsModels, MolecularMolecular Structurehydroxamic acidkinetic resolutionN-heterocyclesstereoelectronic effectssynthetic methods

Identifiers

PMID24839065
PMCPMC4125202

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.