Observational studyHeart and vessels2015
Autoimmunity and pulmonary hypertension in patients with Graves' disease.
Observational study in Heart and vessels, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Association of Graves' disease and Moyamoya syndrome in a Caucasian woman from Western Europe: vascular effects of anti-TSH receptor antibodies?Endocrinology, diabetes & metabolism case reports · 2024Article
- Article
- Symptomatic and severe pulmonary hypertension due to hyperthyroidism.BMJ case reports · 2022Article
- Cor Pulmonale Secondary to Severe Pulmonary Hypertension As the First Manifestation of Graves' Disease.Cureus · 2022Article
- The Role of Thyroid Disorders, Obesity, Diabetes Mellitus and Estrogen Exposure as Potential Modifiers for Pulmonary Hypertension.Journal of clinical medicine · 2022Review
- Impact of achieving euthyroidism on pulmonary artery systolic pressures in hyperthyroidism-associated pulmonary hypertension - a systematic review.American journal of cardiovascular disease · 2022Article
- Ischemia and No Obstructive Coronary Artery Disease and Pulmonary Hypertension in a 16-Year-Old Girl with Unquenched Hyperthyroidism of Graves' Disease.Acta Cardiologica Sinica · 2021Article
- Severe Pulmonary Hypertension and Cholestatic Liver Injury: Two Rare Manifestations of Graves' Disease.Cureus · 2020Article
- Thyroid and Cardiovascular Disease: A Focused Review on the Impact of Hyperthyroidism in Heart Failure.Cardiology research · 2020Review
- Hypertension in Thyroid Disorders.Frontiers in endocrinology · 2019Review
- The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension.International journal of endocrinology · 2019Article
- Echocardiographic evolution of pulmonary hypertension in female patients with hyperthyroidism.Anatolian journal of cardiology · 2018Article
- Right ventricular dysfunction and pulmonary hypertension: a neglected presentation of thyrotoxicosis.Endocrinology, diabetes & metabolism case reports · 2018Article
- Pulmonary hypertension associated with antiphospholipid antibody: Call for a screening tool?Intractable & rare diseases research · 2017Review
- The role of neuropeptides in adverse myocardial remodeling and heart failure.Cellular and molecular life sciences : CMLS · 2017Review
- Atypical Complications of Graves' Disease: A Case Report and Literature Review.Case reports in endocrinology · 2017Article
- Serum-Free Thyroxine Levels Were Associated with Pulmonary Hypertension and Pulmonary Artery Systolic Pressure in Euthyroid Patients with Coronary Artery Disease.International journal of endocrinology · 2017Article
- Pulmonary hypertension in thyroid diseases.Endocrine · 2016Review
- Non-suppressive regulatory T cell subset expansion in pulmonary arterial hypertension.Heart and vessels · 2016Article
- Shortness of Breath and Lower Limb Edema in a 54-Year-Old Woman, Is There Any Cure?Research in cardiovascular medicine · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A link between hyperthyroidism and pulmonary hypertension has been reported, but the underlying mechanisms of these two conditions have not been clearly identified. The aim of this study was to determine the clinical correlates of pulmonary hypertension in patients with Graves' disease. Among 50 consecutive patients with Graves' disease referred for echocardiography, 18 patients (36 %) had pulmonary hypertension measured by continuous-wave Doppler echocardiography (pulmonary artery systolic pressure >35 mmHg). The patients with pulmonary hypertension had significantly higher pulmonary vascular resistance (PVR), cardiac output and thyroid-stimulating hormone receptor antibody (TRAb) compared to those without (p < 0.001, p = 0.028 and p < 0.001, respectively). Pulmonary artery systolic pressure had a good correlation with TRAb (r = 0.74, p < 0.001), but was not related to free T4 (r = 0.12, p = 0.419) and free T3 (r = 0.22, p = 0.126). To determine the important variables present in patients with Graves' disease that may be related to pulmonary artery systolic pressure, 4 variables (PVR, cardiac output, TRAb and free T3) were used in the multivariate analysis. In addition to PVR (standard regression coefficient = 0.831, p < 0.001) and cardiac output (standard regression coefficient = 0.592, p < 0.001), TRAb (standard regression coefficient = 0.178, p < 0.001) emerged as a significant variable related to pulmonary artery systolic pressure. Thus, in addition to the effect of thyroid hormone on the cardiovascular system, autoimmune-mediated pulmonary vascular remodeling may play a role in Graves' disease-linked elevated pulmonary artery systolic pressure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.