ArticleBreast cancer research and treatment2014
Microsatellite genotyping reveals a signature in breast cancer exomes.
Article in Breast cancer research and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Short tandem repeat variants are possibly associated with RNA secondary structure and gene expression.PloS one · 2025Article
- Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species.Journal of evolutionary biology · 2023Review
- Microsatellite Instability Analysis (MSA) for Bladder Cancer: Past History and Future Directions.International journal of molecular sciences · 2021Review
- Germline microsatellite genotypes differentiate children with medulloblastoma.Neuro-oncology · 2020Article
- CAGm: a repository of germline microsatellite variations in the 1000 genomes project.Nucleic acids research · 2019Article
- Article
- Dysfunctional DNA repair pathway via defective FANCD2 gene engenders multifarious exomic and transcriptomic effects in Fanconi anemia.Molecular genetics & genomic medicine · 2018Article
- Family specific genetic predisposition to breast cancer: results from Tunisian whole exome sequenced breast cancer cases.Journal of translational medicine · 2018Article
- Mismatch repair-based stratification for immune checkpoint blockade therapy.American journal of cancer research · 2018Review
- High-depth, high-accuracy microsatellite genotyping enables precision lung cancer risk classification.Oncogene · 2017Article
- Article
- Classification and characterization of microsatellite instability across 18 cancer types.Nature medicine · 2016Article
- A survey of tandem repeat instabilities and associated gene expression changes in 35 colorectal cancers.BMC genomics · 2015Article
- 'Cut from the same cloth': Shared microsatellite variants among cancers link to ectodermal tissues-neural tube and crest cells.Oncotarget · 2015Article
- 3'-UTR poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer with nearly perfect sensitivity.Familial cancer · 2015Article
- Population analysis of microsatellite genotypes reveals a signature associated with ovarian cancer.Oncotarget · 2015Article
- Somatic microsatellite variability as a predictive marker for colorectal cancer and liver cancer progression.Oncotarget · 2015Article
- Applicability of next generation sequencing technology in microsatellite instability testing.Genes · 2015Article
- Exome-wide somatic microsatellite variation is altered in cells with DNA repair deficiencies.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic instability at microsatellite loci is a hallmark of many cancers, including breast cancer. However, much of the genomic variation and many of the hereditary components responsible for breast cancer remain undetected. We hypothesized that variation at microsatellites could provide additional genomic markers for breast cancer risk assessment. A total of 1,345 germline and tumor DNA samples from individuals diagnosed with breast cancer, exome sequenced as part of The Cancer Genome Atlas, were analyzed for microsatellite variation. The comparison group for our analysis, representing healthy individuals, consisted of 249 females which were exome sequenced as part of the 1,000 Genomes Project. We applied our microsatellite-based genotyping pipeline to identify 55 microsatellite loci that can distinguish between the germline of individuals diagnosed with breast cancer and healthy individuals with a sensitivity of 88.4 % and a specificity of 77.1 %. Further, we identified additional microsatellite loci that are potentially useful for distinguishing between breast cancer subtypes, revealing a possible fifth subtype. These findings are of clinical interest as possible risk diagnostics and reveal genes that may be of potential therapeutic value, including genes previously not associated with breast cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.