Evidence map›Paper›PMID 24838834›Full record

ArticleJournal of the National Cancer Institute2014

Stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy.

Matthias Duebgen, Jordi Martinez-Quintanilla, Kaoru Tamura, Shawn Hingtgen, Navid Redjal, Hiroaki Wakimoto, Khalid Shah

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of the National Cancer Institute, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 122 citations in OpenAlex.

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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Matthias DuebgenAffiliations of authors: Molecular Neurotherapy and Imaging Laboratory (MD, JM-Q, SH, NR, HW, KS), Department of Radiology (MD, JM-Q, KT, SH, NR, HW, KS), Department of Neurosurgery (NR, HW), and Department of Neurology (KS), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA (KS).
Jordi Martinez-QuintanillaAffiliations of authors: Molecular Neurotherapy and Imaging Laboratory (MD, JM-Q, SH, NR, HW, KS), Department of Radiology (MD, JM-Q, KT, SH, NR, HW, KS), Department of Neurosurgery (NR, HW), and Department of Neurology (KS), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA (KS).
Kaoru TamuraAffiliations of authors: Molecular Neurotherapy and Imaging Laboratory (MD, JM-Q, SH, NR, HW, KS), Department of Radiology (MD, JM-Q, KT, SH, NR, HW, KS), Department of Neurosurgery (NR, HW), and Department of Neurology (KS), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA (KS).
Shawn HingtgenAffiliations of authors: Molecular Neurotherapy and Imaging Laboratory (MD, JM-Q, SH, NR, HW, KS), Department of Radiology (MD, JM-Q, KT, SH, NR, HW, KS), Department of Neurosurgery (NR, HW), and Department of Neurology (KS), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA (KS).
Navid RedjalAffiliations of authors: Molecular Neurotherapy and Imaging Laboratory (MD, JM-Q, SH, NR, HW, KS), Department of Radiology (MD, JM-Q, KT, SH, NR, HW, KS), Department of Neurosurgery (NR, HW), and Department of Neurology (KS), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA (KS).
Hiroaki WakimotoAffiliations of authors: Molecular Neurotherapy and Imaging Laboratory (MD, JM-Q, SH, NR, HW, KS), Department of Radiology (MD, JM-Q, KT, SH, NR, HW, KS), Department of Neurosurgery (NR, HW), and Department of Neurology (KS), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA (KS).
Khalid ShahAffiliations of authors: Molecular Neurotherapy and Imaging Laboratory (MD, JM-Q, SH, NR, HW, KS), Department of Radiology (MD, JM-Q, KT, SH, NR, HW, KS), Department of Neurosurgery (NR, HW), and Department of Neurology (KS), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA (KS). kshah@mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe current treatment regimen for malignant glioblastoma multiforme (GBM) is tumor resection followed by chemotherapy and radiation therapy. Despite the proven safety of oncolytic herpes simplex virus (oHSV) in clinical trials for GBMs, its efficacy is suboptimal mainly because of insufficient viral spread after tumor resection.

methodsHuman mesenchymal stem cells (MSC) were loaded with oHSV (MSC-oHSV), and their fate was explored by real-time imaging in vitro and in vivo. Using novel diagnostic and armed oHSV mutants and real-time multimodality imaging, the efficacy of MSC-oHSV and its proapoptotic variant, oHSV-TRAIL encapsulated in biocompatible synthetic extracellular matrix (sECM), was tested in different mouse GBM models, which more accurately reflect the current clinical settings of malignant, resistant, and resected tumors. All statistical tests were two-sided.

resultsMSC-oHSVs effectively produce oHSV progeny, which results in killing of GBMs in vitro and in vivo mediated by a dynamic process of oHSV infection and tumor destruction. sECM-encapsulated MSC-oHSVs result in statistically significant increased anti-GBM efficacy compared with direct injection of purified oHSV in a preclinical model of GBM resection, resulting in prolonged median survival in mice (P < .001 with Gehan-Breslow-Wilcoxin test). To supersede resistant tumors, MSC loaded with oHSV-TRAIL effectively induce apoptosis-mediated killing and prolonged median survival in mice bearing oHSV- and TRAIL-resistant GBM in vitro (P < .001 with χ(2) contingency test).

conclusionsHuman MSC loaded with different oHSV variants provide a platform to translate oncolytic virus therapies to clinics in a broad spectrum of GBMs after resection and could also have direct implications in different cancer types.

Indexed as

SimplexvirusAnimalsBrain NeoplasmsFemaleGlioblastomaHumansMesenchymal Stem CellsMiceMice, SCIDOncolytic VirotherapyXenograft Model Antitumor Assays

Identifiers

PMID24838834
OpenAlexW3147094283

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.