ReviewBrain topography2014
Mismatch negativity (MMN) as an index of cognitive dysfunction.
Review in Brain topography, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
100 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neurophysiological alterations during sensory processing in autism - a meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- Mismatch Negativity in First-Episode Schizophrenia: A Meta-Analysis.Clinical EEG and neuroscience · 2017Pooled it
- Dose-Dependent Augmentation of Neuroplasticity-Based Auditory Learning in Schizophrenia: A Double-Blind, Placebo-Controlled, Randomized, Target Engagement Clinical Trial of the NMDA Glutamate Receptor Agonist d-serine.Biological psychiatry · 2023Trial
- Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic MBritish journal of clinical pharmacology · 2021Trial
- Acetylcholine enhances deviance detection in Hodgkin-Huxley neuronal networks.Cognitive neurodynamics · 2026Article
- Mismatch Responses to Prosodic Changes in Children With Developmental Language Disorder: A Longitudinal Approach.The European journal of neuroscience · 2026Article
- Pain Enhances the Auditory P2 but Attenuates Mismatch Response and P3a.European journal of pain (London, England) · 2026Article
- Modulation of Predictive Coding in Auditory Paradigms of Varying Complexity in Children With Developmental Language Disorder.The European journal of neuroscience · 2026Article
- Mismatch negativity-like responses in nitroglycerin-elicited migraine model.Scientific reports · 2026Article
- Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity.Biological psychiatry global open science · 2026Article
- Temporal Dynamics of Auditory Evoked Neural Oscillations Under a Paired-Pulse Suppression Paradigm.Brain sciences · 2026Article
- Effects of neural aging on speech perception in bilinguals vs. monolinguals.Frontiers in human neuroscience · 2026Article
- Multimodal non-invasive approaches for early Alzheimer's disease detection: a review of neuroelectrophysiological and neuroimaging techniques.Frontiers in psychiatry · 2026Review
- Single-channel EEG captures tDCS-induced changes in neural reactivity: a pilot study in disorders of consciousness patients and healthy controls.Therapeutic advances in neurological disorders · 2026Article
- Mismatch Negativity and P3a in Unaffected Siblings of Individuals with Autism Spectrum Disorder and the Exploration on the Neurocognitive Implications.Journal of autism and developmental disorders · 2026Article
- Characteristics of auditory event-related potential and prediction ofQuantitative imaging in medicine and surgery · 2026Article
- Development of an exploratory mismatch negativity-based prognostic nomogram for consciousness recovery in patients with prolonged disorders of consciousness: a derivation study.BMC neurology · 2025Article
- Neurophysiology of mismatch negativity generation: a biophysical modeling study.bioRxiv : the preprint server for biology · 2025Article
- Associations Between Altered Auditory EEG Markers and Clinical Impairments in Fragile X Syndrome.Journal of autism and developmental disorders · 2025Article
- Synaptic Function and Sensory Processing in ZDHHC9-Associated Neurodevelopmental Disorder: A Mechanistic Account.The European journal of neuroscience · 2025Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Cognition is often affected in a variety of neuropsychiatric, neurological, and neurodevelopmental disorders. The neural discriminative response, reflected in mismatch negativity (MMN) and its magnetoencephalographic equivalent (MMNm), has been used as a tool to study a variety of disorders involving auditory cognition. MMN/MMNm is an involuntary brain response to auditory change or, more generally, to pattern regularity violation. For a number of disorders, MMN/MMNm amplitude to sound deviance has been shown to be attenuated or the peak-latency of the component prolonged compared to controls. This general finding suggests that while not serving as a specific marker to any particular disorder, MMN may be useful for understanding factors of cognition in various disorders, and has potential to serve as an indicator of risk. This review presents a brief history of the MMN, followed by a description of how MMN has been used to index auditory processing capability in a range of neuropsychiatric, neurological, and neurodevelopmental disorders. Finally, we suggest future directions for research to further enhance our understanding of the neural substrate of deviance detection that could lead to improvements in the use of MMN as a clinical tool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.