ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2014
Temporal effect of in vivo tendon fatigue loading on the apoptotic response explained in the context of number of fatigue loading cycles and initial damage parameters.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Platelet-Rich Plasma (PRP): Molecular Mechanisms, Actions and Clinical Applications in Human Body.International journal of molecular sciences · 2025Review
- Loadless Tendon Explant Model Exhibits Spontaneous Degradative Phenotypes: AnJournal of clinical medicine research · 2025Article
- The Natural History of the Development and Resolution of Achilles and Patellar Tendon Sonographic Abnormalities in a Collegiate Cohort.Translational sports medicine · 2025Article
- Successive tendon injury in anFrontiers in bioengineering and biotechnology · 2024Article
- A passive ankle dorsiflexion testing system to assess mechanobiological and structural response to cyclic loading in rat Achilles tendon.Journal of biomechanics · 2023Article
- Establishing in vivo and ex vivo chick embryo models to investigate fetal tendon healing.Scientific reports · 2023Article
- An Adolescent Murine In Vivo Anterior Cruciate Ligament Overuse Injury Model.The American journal of sports medicine · 2023Article
- Ultrasound evaluation of the patellar tendon and Achilles tendon and its association with future pain in distance runners.The Physician and sportsmedicine · 2021Article
- Tendinopathy and tendon material response to load: What we can learn from small animal studies.Acta biomaterialia · 2021Review
- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life.Advances in experimental medicine and biology · 2021Review
- Platelet-Rich Plasma Therapy in the Treatment of Diseases Associated with Orthopedic Injuries.Tissue engineering. Part B, Reviews · 2020Review
- High cholesterol induces apoptosis and autophagy through the ROS-activated AKT/FOXO1 pathway in tendon-derived stem cells.Stem cell research & therapy · 2020Article
- Mechanical stress-induced cell death in breast cancer cells.Biology open · 2019Article
- Multiscale mechanisms of tendon fatigue damage progression and severity are strain and cycle dependent.Journal of biomechanics · 2019Article
- Load transfer, damage, and failure in ligaments and tendons.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Promoting effective tendon healing and remodeling.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Inhibition of apoptosis exacerbates fatigue-damage tendon injuries in an in vivo rat model.European cells & materials · 2018Article
- A potential new role for myofibroblasts in remodeling of sub-rupture fatigue tendon injuries by exercise.Scientific reports · 2018Article
- Novel image analysis methods for quantification of in situ 3-D tendon cell and matrix strain.Journal of biomechanics · 2018Article
- Tendinopathy: Investigating the Intersection of Clinical and Animal Research to Identify Progress and Hurdles in the Field.JBJS reviews · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Accumulation of damage is a leading factor in the development of tendinopathy. Apoptosis has been implicated in tendinopathy, but the biological mechanisms responsible for initiation and progression of these injuries are poorly understood. We assessed the relationship between initial induced damage and apoptotic activity 3 and 7 days after fatigue loading. We hypothesized that greater apoptotic activity (i) will be associated with greater induced damage and higher number of fatigue loading cycles, and (ii) will be higher at 7 than at 3 days after loading. Left patellar tendons were fatigue loaded for either 100 or 7,200 cycles. Diagnostic tests were applied before and after fatigue loading to determine the effect of fatigue loading on hysteresis, elongation, and loading and unloading stiffness (damage parameters). Cleaved Caspase-3 staining was used to identify and calculate the percent apoptosis in the patellar tendon. While no difference in apoptotic activity occurred between the 100 and 7,200 cycle groups, greater apoptotic activity was associated with greater induced damage. Apoptotic activity was higher at 7 than 3 days after loading. We expect that the decreasing number of healthy cells that can repair the induced damage in the tendon predispose it to further injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.