ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2014
Borrelia burgdorferi sensu lato serology in the Netherlands: guidelines versus daily practice.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The diagnostic accuracy of serological tests for Lyme borreliosis in Europe: a systematic review and meta-analysis.BMC infectious diseases · 2016Pooled it
- An intervention in general practice to improve the management of Lyme borreliosis in Denmark.European journal of public health · 2022Trial
- Article
- Prevalence and factors associated with a prescription of a Lyme borreliosis serology for erythema migrans diagnosis in general practice: a study from the French sentinel network, 2009-2020.BMC primary care · 2023Article
- Seroprevalence of antibodies against Borrelia burgdorferi sensu lato in healthy blood donors in Romania: an update.Parasites & vectors · 2021Article
- Serodiagnosis of Lyme borreliosis-is IgM in serum more harmful than helpful?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Observational
- Serological testing for Lyme Borreliosis in general practice: A qualitative study among Dutch general practitioners.The European journal of general practice · 2020Article
- Diagnostic parameters of modified two-tier testing in European patients with early Lyme disease.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- The French Society of Internal Medicine's Top-5 List of Recommendations: a National Web-Based Survey.Journal of general internal medicine · 2019Article
- Serological Diagnostics of Lyme Borreliosis: Comparison of Universal and Borrelia Species-Specific Tests Based on Whole-Cell and Recombinant Antigens.Journal of clinical microbiology · 2018Article
- Diagnostic behaviour of general practitioners when suspecting Lyme disease: a database study from 2010-2015.BMC family practice · 2018Observational
- Diagnostic impact of routine Lyme serology in recent-onset arthritis: results from the ESPOIR cohort.RMD open · 2016Article
- Vector-borne disease intelligence: strategies to deal with disease burden and threats.Frontiers in public health · 2014Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to compare guideline recommendations and day-to-day practice of serological testing for Lyme borreliosis (LB) in a laboratory located in Amsterdam, the Netherlands, serving both regional hospitals and primary care physicians. By telephone interview, we obtained clinical information regarding 488 requests for LB serology. Screening for LB was performed with a C6-peptide EIA and confirmed by recombinant immunoblot. A total of 82 % of the requests were not supported by guideline's recommendations and either originated from patients with atypical symptoms and a low a priori chance for LB or from patients for which testing on LB was not recommended for other reasons. C6-EIA screening was positive in 5 % of patients with atypical symptoms, comparable to the seroprevalence in the Dutch population. Interestingly, 10 % of the requests were from patients with atypical skin lesions, of which 20 % was positive, suggesting that serological testing is of additional value in a selection of such patients. Strikingly, only 9 % of the requests were supported by recommendations by guidelines. The percentage of positive confirmatory IgM and/or IgG immunoblots did not differ substantially between the groups and ranged from 56 to 75 %. Guidelines for testing for LB are not adequately followed in the Netherlands. Better education and adherence to the guidelines by physicians could prevent unnecessary diagnostics and antibiotic treatment of supposed LB patients.
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