ReviewSeminars in immunopathology2014
Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease.
Review in Seminars in immunopathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
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- Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023.Antibiotics (Basel, Switzerland) · 2023Review
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- Cellular infiltration in traumatic brain injury.Journal of neuroinflammation · 2020Review
- In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid Fractions.Nutrients · 2020Article
- Cancer incidence in familial Mediterranean fever patients: a retrospective analysis from central Anatolia.Rheumatology international · 2019Article
- Right place, right time: localisation and assembly of the NLRP3 inflammasome.F1000Research · 2019Review
- Molecular Targets in Hepatocarcinogenesis and Implications for Therapy.Journal of clinical medicine · 2018Review
- Expression and regulation of alarmin cytokine IL-1α in human retinal pigment epithelial cells.Experimental eye research · 2018Article
- Betaine Inhibits Interleukin-1β Production and Release: Potential Mechanisms.Frontiers in immunology · 2018Review
- Inflammasomes and Cancer: The Dynamic Role of the Inflammasome in Tumor Development.Frontiers in immunology · 2017Review
- Targeting inflammasome/IL-1 pathways for cancer immunotherapy.Scientific reports · 2016Article
- Monosodium urate crystal-induced pro-interleukin-1β production is post-transcriptionally regulated via the p38 signaling pathway in human monocytes.Scientific reports · 2016Article
- Autoinflammatory Skin Disorders: The Inflammasomme in Focus.Trends in molecular medicine · 2016Review
- Emerging Roles for the Immune System in Traumatic Brain Injury.Frontiers in immunology · 2016Review
- Article
- Review
- The Role of Damage-Associated Molecular Patterns in Human Diseases: Part I - Promoting inflammation and immunity.Sultan Qaboos University medical journal · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In recent years, non-communicable chronic diseases that are potentiated by sterile inflammation have replaced infectious diseases as the major threat to human health. Sterile inflammation that results from aberrant tissue damage plays pivotal roles in the pathogenesis of numerous acute and chronic inflammatory diseases including atherosclerosis, type 2 diabetes, cancer, obesity, and multiple neurodegenerative diseases. The cellular events and molecular signaling pathways that govern sterile inflammation currently remain poorly defined; however, emerging data suggest central roles for IL-1 in driving autoimmune and inflammatory disease pathogenesis. Improved characterization of the immunological pathways that contribute to sterile inflammation are desperately needed to develop effective therapeutics to treat these devastating diseases. In this review, we discuss recent advances in our understanding of how IL-1 is regulated in response to tissue damage. In particular, we highlight recent studies that describe novel roles for conventional cell death molecules in the regulation of IL-1β production.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.