ArticleNeurochemical research2014
Neuron specific enolase and c-reactive protein levels in stroke and its subtypes: correlation with degree of disability.
Article in Neurochemical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Prognostic value of serial IL-6 and NSE measurements in acute ischemic stroke patients undergoing mechanical thrombectomy.eNeurologicalSci · 2026Article
- Ischemic stroke neuroprotection revisited: translational barriers and a phase-resolved, biomarker-anchored framework.Archives of pharmacal research · 2026Review
- Association of serum Netrin-1, NSE, and S100β with brain injury severity and prognosis in patients with sepsis-associated encephalopathy.Biomolecules & biomedicine · 2025Article
- Emerging biomarkers in ischemic stroke.Vessel plus · 2025Article
- Neuron-specific enolase as a prognostic biomarker in acute ischemic stroke patients treated with reperfusion therapies.Frontiers in neurology · 2024Article
- A review of theFrontiers in pharmacology · 2024Review
- Predictors of Early Neurological Deterioration and Functional Outcome in Acute Ischemic Stroke: The Importance of Large Artery Disease, Hyperglycemia and Inflammatory Blood Biomarkers.Neuropsychiatric disease and treatment · 2022Article
- Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients.Journal of neurotrauma · 2021Review
- Intra-arterial thrombectomy for acute ischaemic stroke patients with active cancer.Journal of neurology · 2019Article
- Association of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio with Treatment Modalities of Acute Ischaemic Stroke: A Pilot Study.Medicina (Kaunas, Lithuania) · 2019Article
- Inflammation is correlated with severity and outcome of cerebral venous thrombosis.Journal of neuroinflammation · 2018Article
- Predicting functional outcome of ischemic stroke patients in Romania based on plasma CRP, sTNFR-1, D-Dimers, NGAL and NSE measured using a biochip array.Acta pharmacologica Sinica · 2018Article
- GWAS-Supported CRP Gene Polymorphisms and Functional Outcome of Large Artery Atherosclerotic Stroke in Han Chinese.Neuromolecular medicine · 2018Article
- New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection.Brain sciences · 2018Review
- Plasma Translocator Protein Levels and Outcomes of Acute Ischemic Stroke: A Pilot Study.Disease markers · 2018Article
- Serum neuron specific enolase is increased in pediatric acute encephalitis syndrome.Korean journal of pediatrics · 2017Article
- Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke.International journal of molecular sciences · 2016Review
- Biological Variation and Reference Change Value Data for Serum Neuron-Specific Enolase in a Turkish Population.Journal of clinical laboratory analysis · 2016Article
- A Rich-Club Organization in Brain Ischemia Protein Interaction Network.Scientific reports · 2015Article
- The role of hs-CRP, D-dimer and fibrinogen in differentiating etiological subtypes of ischemic stroke.PloS one · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is an emergency which threatens life and third leading cause of death and long term disability in developed countries. The use of biomarkers in diagnosing stroke and assessing prognosis is an emerging and rapidly evolving field. The study aimed to investigate the predictive value of biochemical marker of brain damage neuron-specific enolase (NSE) and systemic inflammatory marker C-reactive protein (CRP) with respect to degree of disability at the time of admission and short term in stroke patients. We investigated 120 patients with cerebrovascular stroke who were admitted within 72 h of onset of stroke in the Department of Neurology at Sri Aurobindo Institute of Medical Sciences, Indore, India. NSE and CRP were analyzed by solid enzyme linked immunosorbent assay using analyzer and micro plate reader from Biorad 680. In all patients, the neurological status was evaluated by a standardized neurological examination and the National Institutes of Health Stroke Scale on admission and on day 7. Serum NSE and CRP concentration were found significantly increased in acute stroke cases as compared to control in present study (<0.05 and <0.001 respectively). The maximum serum NSE and CRP levels within 72 h of admission were significantly higher in patients with greater degree of disability at the time of admission. Both biomarkers were found significantly correlated with neurological disability and short term outcome. Our study showed that serum biomarkers NSE and CRP have high predictive value for determining severity and early neurobehavioral outcome after acute stroke.
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