SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2015
Intrawound vancomycin to prevent infections after spine surgery: a systematic review and meta-analysis.
Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Topical Gentamicin and Vancomycin for Surgical Site Infection Prophylaxis in Patients Undergoing High-Risk Vascular Surgery
The Effect of Intrawound Vancomycin Powder in Spine Surgery: A Prospective Randomized Controlled Trial
Who cites it
35 citing papers in PubMed, 6 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- A meta-analysis examining the impact of intrawound treatment on reducing deep surgical site infections during instrumented spine surgery.International wound journal · 2024Pooled it
- Effect of powdered vancomycin on stopping surgical site wound infections in neurosurgery: A meta-analysis.International wound journal · 2023Pooled it
- Irrigation techniques used in spine surgery for surgical site infection prophylaxis: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2022Pooled it
- APSIC guidelines for the prevention of surgical site infections.Antimicrobial resistance and infection control · 2019Guideline
- Effect of Intra-wound Vancomycin for Spinal Surgery: A Systematic Review and Meta-analysis.Orthopaedic surgery · 2017Pooled it
- Methylprednisolone for the Treatment of Patients with Acute Spinal Cord Injuries: A Systematic Review and Meta-Analysis.Journal of neurotrauma · 2016Pooled it
- Local vancomycin therapy to reduce surgical site infection in adult spine surgery: a randomized prospective study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Trial
- Intrawound application of vancomycin changes the responsible germ in elective spine surgery without significant effect on the rate of infection: a randomized prospective study.Musculoskeletal surgery · 2018Trial
- Propellant-free intrawound antibiotic foam for intraoperative antimicrobial prophylaxis.Drug delivery and translational research · 2026Article
- Nomogram for the prediction of surgical site infection following spinal surgery: a multicenter retrospective study.Frontiers in medicine · 2026Article
- Impact of Local Vancomycin on Postoperative Outcomes in Ankle Arthrodesis: A Propensity-Matched Cohort Study.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- Prevalence and Risk Factors of Postoperative Spinal Infections: A Five-year Study in Northwestern Iran.Archives of Iranian medicine · 2025Article
- A technique for introducing broad-spectrum topical antibiotics during open reduction and internal fixation of acetabular fractures.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- RETRACTED: Effect of intra-wound vancomycin on the surgical site wound infection after spinal surgery: A meta-analysis.International wound journal · 2024Review
- Surgical Site Infection Prophylaxis and Wound Management in Spine Surgery.Asian spine journal · 2022Article
- Article
- Is Use of Topical Vancomycin in Pediatric Spine Surgeries a Safe Option in the Prevention of Surgical Site Infections? A Meta-analysis and Systematic Review of the Literature.Global spine journal · 2021Article
- Adjuvant antibiotic-loaded bone cement: Concerns with current use and research to make it work.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- The Cost-Effectiveness of Vancomycin Powder in Lumbar Laminectomy.Global spine journal · 2021Article
- [Effect of hydrogen peroxide on anti-infection and reducing postoperative drainage in multi-segmental lumbar surgery].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePost-operative spine surgical site infections are associated with substantial morbidity, mortality, and economic burden. Intrawound vancomycin may prevent infections after spine surgery, but recent studies have reported conflicting results. The objectives of this systematic review and meta-analysis were to determine: (1) In patients undergoing spine surgery, does the application of intrawound vancomycin lead to reduced rates of post-operative surgical site infections? (2) Are there differences in the estimates of effect between observational studies and randomized trials? (3) What adverse events are reported in the literature?
methodsAll published comparative studies of intrawound vancomycin in spine surgery were included. Two reviewers independently screened eligible articles and assessed study quality. Observational studies and randomized trials were pooled separately using a random-effects model.
resultsEight observational studies and one randomized controlled trial met the inclusion criteria. Across observational studies, the odds of infection with intrawound vancomycin was 0.19 times the odds of infection without intrawound vancomycin (95 % CI 0.08-0.47, p = 0.0003, I (2) = 52 %). The single randomized controlled trial produced a conflicting result (OR 0.96, 95 % CI 0.34-2.66, p = 0.93). There were no adverse events attributable to intrawound vancomycin. The quality of the evidence was low or very low.
conclusionsThere is a lack of high-quality evidence to inform the use of intrawound vancomycin in spine surgery. Surgeons should be cautious before widely adopting this intervention and should be vigilant in monitoring for adverse effects. Further investigation with additional randomized controlled trials is justified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.