ArticleDigestive diseases and sciences2014
Mucosal healing predicts the long-term prognosis of intestinal Behçet's disease.
Article in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Efficacy and Safety of Infliximab in Intestinal Behçet's Disease: A Multicenter, Phase 3 Study (BEGIN).Gut and liver · 2023Trial
- Trial
- Treat-to-target in Behçet syndrome.Nature reviews. Rheumatology · 2026Review
- Development and validation of a novel intestinal ultrasound score for predicting endoscopic activity of ileocecal ulcers in intestinal Behçet's disease.Journal of gastroenterology · 2026Article
- Evidence-based diagnosis and clinical practice guidelines for intestinal Behçet's disease 2020 edited by Intractable Diseases, the Health and Labour Sciences Research Grants.Journal of gastroenterology · 2020Article
- Poor prognostic factors in patients with newly diagnosed intestinal Adamantiades-Behçet's disease in the Shanghai Adamantiades-Behçet's disease database: a prospective cohort study.Orphanet journal of rare diseases · 2019Article
- Development of a Novel Endoscopic Scoring System to Predict Relapse after Surgery in Intestinal Behçet's Disease.Gut and liver · 2018Article
- Treatment and outcomes: medical and surgical treatment for intestinal Behçet's disease.Intestinal research · 2017Review
- Optimal diagnosis and disease activity monitoring of intestinal Behçet's disease.Intestinal research · 2017Review
- Risk factors and outcomes of acute lower gastrointestinal bleeding in intestinal Behçet's disease.International journal of colorectal disease · 2017Article
- Intestinal Behçet's Disease: A True Inflammatory Bowel Disease or Merely an Intestinal Complication of Systemic Vasculitis?Yonsei medical journal · 2016Review
- Outcome predictors for intestinal Behçet's disease.Yonsei medical journal · 2013Review
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Authors and funding
9 authors.
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Abstract
backgroundMucosal healing (MH) has emerged as a therapeutic goal in the treatment of inflammatory bowel disease; however, little is known about the impact of MH on the prognosis of intestinal Behçet's disease (BD).
aimWe investigated whether MH could predict the prognosis of intestinal BD.
methodsWe retrospectively reviewed the medical records of 80 patients with intestinal BD who underwent colonoscopy within 3 months after clinical remission. The clinical recurrence rate according to the presence or absence of MH was evaluated using the Kaplan-Meier method and the log-rank test. In order to evaluate MH as an independent prognostic factor, a multivariate analysis using Cox proportional hazards regression model was performed including other potential factors for the relapse of intestinal BD.
resultsThe number of patients with active ulcers at the time of clinical remission was 57 (71.3%), while 23 patients (28.7%) were experiencing MH. In the active ulcer group, 39 patients (68.4%) experienced recurrence during the follow-up period, whereas 7 patients (30.4%) recurred in the MH group. The cumulative recurrence rate was significantly higher in the active ulcer group than in the MH group (P < 0.001). A multivariate analysis identified active ulcers at the time of clinical remission as an independent predictive factor for relapse.
conclusionOur study demonstrates that MH is an independent factor predictive of long-term prognosis of intestinal BD. MH might be the ultimate therapeutic goal in the treatment of intestinal BD.
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