Evidence map›Paper›PMID 24838168›Full record

ArticleNature chemical biology2014

Structural biology: a 'funny' cyclic dinucleotide receptor.

Yoni Haitin

Abstract readComment
PubMed Publisher
In one paragraph

Article in Nature chemical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review: HCN Channels in the Heart.Current cardiology reviews · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Yoni HaitinDepartment of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deciphering the molecular basis of HCN channel regulation by cGMP leads to the serendipitous discovery of cyclic dinucleotides as potent inhibitors of I(f) current in the heart.

Indexed as

AnimalsCyclic AMPCyclic GMPDinucleoside PhosphatesHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsIon Channel GatingMuscle ProteinsPotassium Channelsbis(3',5')-cyclic diguanylic acidCyclic AMPcyclic diadenosine phosphateCyclic GMPDinucleoside PhosphatesHCN4 protein, humanHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMuscle ProteinsPotassium Channels

Identifiers

PMID24838168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.