ReviewActa paediatrica (Oslo, Norway : 1992)2014
Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia?
Review in Acta paediatrica (Oslo, Norway : 1992), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of a New Technique -"IN-REC-SUR-E"- in Preterm Neonates With Respiratory Distress Syndrome During Non Invasive Ventilation: a Randomized Controlled Trial
Nasal HFOV vs Nasal CPAP: Effects on Gas Exchange for the Treatment of Neonates Recovering From Respiratory Distress Syndrome. A Multicenter Randomized Controlled Trial
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Automated oxygen delivery for preterm infants with respiratory dysfunction.The Cochrane database of systematic reviews · 2023Pooled it
- Oxygen saturation targeting by pulse oximetry in the extremely low gestational age neonate: a quixotic quest.Current opinion in pediatrics · 2017Pooled it
- Oxygen Saturation Targets in Preterm Infants and Outcomes at 18-24 Months: A Systematic Review.Pediatrics · 2017Pooled it
- The effect of head positioning on brain tissue oxygenation in preterm infants: a randomized clinical trial study.Journal of perinatology : official journal of the California Perinatal Association · 2022Trial
- Trial
- Oxygen Saturation Target Achievement in Preterm Infants <32 Weeks' Gestation with 9Research square · 2026Article
- Retinopathy of prematurity and cognitive development in enteral docosahexaenoic acid-supplemented preterm infants: a systematic review and meta-analysis.Translational pediatrics · 2026Article
- Evaluation of Fentanyl-Emerged Adverse Events and Pharmacokinetics in Neonates: A Physiologically Based Pharmacokinetic Modeling Approach.Clinical pharmacokinetics · 2025Article
- Oxygenation Practices During General Anesthesia in Pediatric Patients: An International Survey in Europe, USA, Australia, and New Zealand.Paediatric anaesthesia · 2025Article
- Trends in bronchopulmonary dysplasia and 15-year evolution in respiratory and hemodynamic management of very premature infants.Scientific reports · 2025Observational
- Revolutionizing Neonatal Care: A Comprehensive Review of Intact Cord Resuscitation in Newborns.Cureus · 2024Review
- Association of extreme hyperoxemic events and mortality in pediatric critical care: an observational cohort study.Frontiers in pediatrics · 2024Article
- Knowledge, Practice, and Associated Factors Towards Supplemental Oxygen Therapy Among Nurses Working in Neonatal Intensive Care Units in Public Hospitals of Addis Ababa, Ethiopia, 2022: A Cross-Sectional Study.Pediatric health, medicine and therapeutics · 2024Article
- Determining an Optimal Oxygen Saturation Target Range Based on Neonatal Maturity: Demonstration of a Decision Tree Analytic.Diagnostics (Basel, Switzerland) · 2023Article
- SLAB51 Multi-Strain Probiotic Formula Increases Oxygenation in Oxygen-Treated Preterm Infants.Nutrients · 2023Article
- Early Surfactant Therapy for Respiratory Distress Syndrome in Very Preterm Infants.Healthcare (Basel, Switzerland) · 2023Article
- Reducing the time delay of oxygen transport to the neonate on continuous positive airway pressure support: A bench study.Frontiers in pediatrics · 2023Article
- Preterm infant retinal OCT markers of perinatal health and retinopathy of prematurity.Frontiers in pediatrics · 2023Review
- Incidence of death and its predictors among neonates admitted with sepsis in referral hospitals, northwest Ethiopia, a prospective cohort study.Frontiers in pediatrics · 2023Article
- Transfontanelle photoacoustic imaging for in-vivo cerebral oxygenation measurement.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 10 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledOxygen is a neonatal health hazard that should be avoided in clinical practice. In this review, an international team of neonatologists and nurses assessed oxygen saturation (SpO2 ) targeting in preterm infants and evaluated the potential weaknesses of randomised clinical trials.
conclusionSpO2 of 85-89% can increase mortality and 91-95% can cause hyperoxia and ill effects. Neither of these ranges can be recommended, and wider intermediate targets, such as 87-94% or 88-94%, may be safer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.