ReviewMolecules (Basel, Switzerland)2014
Ultraviolet radiation, aging and the skin: prevention of damage by topical cAMP manipulation.
Review in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
127 citing papers in PubMed, 2 syntheses or guidelines pooled it, 342 citations in OpenAlex.
- How Strong Is the Link Between Merkel Cell Carcinoma and the Occurrence of Other Skin Cancer Types? A Meta-Analysis.Experimental dermatology · 2025Pooled it
- Cumulative Erythemal Ultraviolet Radiation and Risk of Cancer in 3 Large US Prospective Cohorts.American journal of epidemiology · 2022Pooled it
- Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.Frontiers in aging · 2025Trial
- Clinical Evidence of Effects of Green Mandarin (Putgyul) Extract on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study.Nutrients · 2022Trial
- Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial.Scientific reports · 2019Trial
- A Specific Melon Concentrate Exhibits Photoprotective Effects from Antioxidant Activity in Healthy Adults.Nutrients · 2018Trial
- Skin Aging: From Molecular Mechanisms to Therapeutic and Technological Innovations.Journal of cellular and molecular medicine · 2026Review
- Multi-omics characterization of the skin microbiota reveals the anti-aging roles of Stenotrophomonas maltophilia.Microbiome · 2026Article
- Bioinspired Melanoidin-Polyphenol nanocomplex for hair protection and mechanical reinforcement with antioxidant activity.Materials today. Bio · 2026Article
- Antioxidant, Photoprotective, and Antimicrobial Potential of Oil Extract ofMolecules (Basel, Switzerland) · 2026Article
- Insights into Tanning Biology and Tanning Products.The Journal of clinical and aesthetic dermatology · 2026Review
- Harnessing the potential of selected Himalayan species for phyto-cosmeceutical formulations guided through biochemometric analysis.Scientific reports · 2026Article
- Prevalence, incidence, and risk factors for dermatologic conditions in people with HIV in the modern antiretroviral era: A cohort study in Washington, DC.Journal of the American Academy of Dermatology · 2026Article
- Integrative Machine Learning of Genetic and Lifestyle Factors for Personalized Skin Health.IEEE journal of translational engineering in health and medicine · 2026Article
- Topical oleic acid reduces nociception and inflammation in a UVB radiation-induced sunburn model in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Burdens of Malignant Melanoma and Projections for 2050 in Asia: Findings from the 2023 Global Burden of Disease Study.Clinical, cosmetic and investigational dermatology · 2026Article
- Notoginsenoside R1 mitigates UVB-induced skin sunburn injury through modulation of NChinese medicine · 2025Article
- Efficacy of an Oral Skincare Supplement on Skin Aging: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial.Dermatology and therapy · 2025Article
- Preventive and Therapeutic Interventions in Solar Elastosis and Photoaging: A Comprehensive Systematic Review.Biomedicines · 2025Review
- SkinspanMayo Clinic proceedings · 2025Review
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Being the largest and most visible organ of the body and heavily influenced by environmental factors, skin is ideal to study the long-term effects of aging. Throughout our lifetime, we accumulate damage generated by UV radiation. UV causes inflammation, immune changes, physical changes, impaired wound healing and DNA damage that promotes cellular senescence and carcinogenesis. Melanoma is the deadliest form of skin cancer and among the malignancies of highest increasing incidence over the last several decades. Melanoma incidence is directly related to age, with highest rates in individuals over the age of 55 years, making it a clear age-related disease. In this review, we will focus on UV-induced carcinogenesis and photo aging along with natural protective mechanisms that reduce amount of "realized" solar radiation dose and UV-induced injury. We will focus on the theoretical use of forskolin, a plant-derived pharmacologically active compound to protect the skin against UV injury and prevent aging symptoms by up-regulating melanin production. We will discuss its use as a topically-applied root-derived formulation of the Plectranthus barbatus (Coleus forskolii) plant that grows naturally in Asia and that has long been used in various Aryuvedic teas and therapeutic preparations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.