ReviewNeuroscience2014
The challenge of understanding cerebral white matter injury in the premature infant.
Review in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 70 citations in OpenAlex.
- Feasibility of event-related potential (ERP) biomarker use to study effects of mother's voice exposure on speech sound differentiation of preterm infants.Developmental neuropsychology · 2018Trial
- Multi-level static and dynamic graph-theoretical analyses of resting-state functional networks in a Chinese cohort of preterm neonates.iScience · 2026Article
- The influence of nutrition on white matter development in preterm infants: a scoping review.Pediatric research · 2026Article
- Motion perception and biological motion processing in adults born with extremely low birth weight.Scientific reports · 2026Article
- Human umbilical cord mesenchymal stem cells alleviate hypoxic-ischemia-induced white-matter injury in neonatal rats by regulating polarization of microglia.Scientific reports · 2026Article
- Hyperoxia Induced Hypomyelination.Biomedicines · 2022Article
- Oxidative Stress in Preterm Newborns.Antioxidants (Basel, Switzerland) · 2021Review
- Acute brain inflammation, white matter oxidative stress, and myelin deficiency in a model of neonatal intraventricular hemorrhage.Journal of neurosurgery. Pediatrics · 2020Article
- Oligodendrocyte Response to Pathophysiological Conditions Triggered by Episode of Perinatal Hypoxia-Ischemia: Role of IGF-1 Secretion by Glial Cells.Molecular neurobiology · 2020Article
- Glutamate Transporters: Expression and Function in Oligodendrocytes.Neurochemical research · 2020Article
- Article
- Hybrid PET/MRI imaging in healthy unsedated newborn infants with quantitative rCBF measurements usingJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Synaptic Injury in the Thalamus Accompanies White Matter Injury in Hypoxia/Ischemia-Mediated Brain Injury in Neonatal Rats.BioMed research international · 2019Article
- Catalpol Inhibits Ischemia-Induced Premyelinating Oligodendrocyte Damage through Regulation of Intercellular Calcium Homeostasis via Na⁺/CaInternational journal of molecular sciences · 2018Article
- Hubs in the human fetal brain network.Developmental cognitive neuroscience · 2018Article
- Variants of the EAAT2 Glutamate Transporter Gene Promoter Are Associated with Cerebral Palsy in Preterm Infants.Molecular neurobiology · 2018Article
- Monocarboxylate transporter 1 and the vulnerability of oligodendrocyte lineage cells to metabolic stresses.CNS neuroscience & therapeutics · 2018Article
- Oxidative Stress as a Primary Risk Factor for Brain Damage in Preterm Newborns.Frontiers in pediatrics · 2018Review
- Neuroprotective Effect of Chitosan Oligosaccharide on Hypoxic-Ischemic Brain Damage in Neonatal Rats.Neurochemical research · 2017Article
- [Long-term effect of oligodendrocyte precursor cell transplantation on a rat model of white matter injury in the preterm infant].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
White matter injury in the premature infant leads to motor and more commonly behavioral and cognitive problems that are a tremendous burden to society. While there has been much progress in understanding unique vulnerabilities of developing oligodendrocytes over the past 30years, there remain no proven therapies for the premature infant beyond supportive care. The lack of translational progress may be partially explained by the challenge of developing relevant animal models when the etiology remains unclear, as is the case in this disorder. There has been an emphasis on hypoxia-ischemia and infection/inflammation as upstream etiologies, but less consideration of other contributory factors. This review highlights the evolution of white matter pathology in the premature infant, discusses the prevailing proposed etiologies, critically analyzes a sampling of common animal models and provides detailed support for our hypothesis that nutritional and hormonal deprivation may be additional factors playing critical and overlooked roles in white matter pathology in the premature infant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.