ArticleDrug and alcohol dependence2014
Differential reward network functional connectivity in cannabis dependent and non-dependent users.
Article in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Patterns of brain function associated with cannabis cue-reactivity in regular cannabis users: a systematic review of fMRI studies.Psychopharmacology · 2021Pooled it
- Age- and Sex-Related Cortical Gray Matter Volume Differences in Adolescent Cannabis Users: A Systematic Review and Meta-Analysis of Voxel-Based Morphometry Studies.Frontiers in psychiatry · 2021Pooled it
- The hyper-sentient addict: an exteroception model of addiction.The American journal of drug and alcohol abuse · 2015Pooled it
- Testing the role of the posterior cingulate cortex in processing salient stimuli in cannabis users: an rTMS study.The European journal of neuroscience · 2019Trial
- Positive face BOLD response and task-dependent ventral striatal functional connectivity during Go/No-go task among abstinent cannabis-using adolescents and young adults.Frontiers in adolescent medicine · 2026Article
- Increased Mesostriatal Intrinsic Connectivity Associated With Cue Exposure in Adult Cannabis Users: Preliminary Findings.Addiction biology · 2025Article
- Exploring the Utility of a Functional Magnetic Resonance Imaging Cannabis Cue-Reactivity Paradigm in Treatment-Seeking Adults With Cannabis Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Altered functional connectivity and oscillatory dynamics in polysubstance and cannabis only users during visuospatial processing.Psychopharmacology · 2023Article
- Value-based decision-making network functional connectivity correlates with substance use and delay discounting behaviour among young adults.NeuroImage. Clinical · 2023Article
- A Meta-Analysis of fMRI Studies of Youth Cannabis Use: Alterations in Executive Control, Social Cognition/Emotion Processing, and Reward Processing in Cannabis Using Youth.Brain sciences · 2022Article
- The Construct of Medical and Non-Medical Marijuana-Critical Review.International journal of environmental research and public health · 2022Review
- Functional brain connectomes reflect acute and chronic cannabis use.Scientific reports · 2022Article
- DLPFC stimulation alters large-scale brain networks connectivity during a drug cue reactivity task: A tDCS-fMRI study.Frontiers in systems neuroscience · 2022Article
- Cannabis Use and Neuroadaptation: A Call for ΔFrontiers in psychiatry · 2022Article
- Examining Inhibitory Affective Processing Within the Rostral Anterior Cingulate Cortex Among Abstinent Cannabis-Using Adolescents and Young Adults.Frontiers in psychiatry · 2022Article
- Relationship between BMI and alcohol consumption levels in decision making.International journal of obesity (2005) · 2021Article
- Repetitive transcranial magnetic stimulation as a potential treatment approach for cannabis use disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Altered fronto-occipital connectivity during visual selective attention in regular cannabis users.Psychopharmacology · 2021Article
- Synergistic effects of HIV and marijuana use on functional brain network organization.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEmergent studies show that similar to other substances of abuse, cue-reactivity to cannabis is also associated with neural response in the brain's reward pathway (Filbey et al., 2009). However, the inter-relatedness of brain regions during cue-reactivity in cannabis users remains unknown.
methodsIn this study, we conducted a series of investigations to determine functional connectivity during cue-reactivity in 71 cannabis users. First, we used psychophysiological interaction (PPI) analysis to examine coherent neural response to cannabis cues. Second, we evaluated whether these patterns of network functional connectivity differentiated dependent and non-dependent users. Finally, as an exploratory analysis, we determined the directionality of these connections via Granger connectivity analyses.
resultsPPI analyses showed reward network functional connectivity with the nucleus accumbens (NAc) seed region during cue exposure. Between-group contrasts found differential effects of dependence status. Dependent users (N=31) had greater functional connectivity with amygdala and anterior cingulate gyrus (ACG) seeds while the non-dependent users (N=24) had greater functional connectivity with the NAc, orbitofrontal cortex (OFC) and hippocampus seeds. Granger analyses showed that hippocampal and ACG activation preceded neural response in reward areas.
conclusionsBoth PPI and Granger analyses demonstrated strong functional coherence in reward regions during exposure to cannabis cues in current cannabis users. Functional connectivity (but not regional activation) in the reward network differentiated dependent from non-dependent cannabis users. Our findings suggest that repeated cannabis exposure causes observable changes in functional connectivity in the reward network and should be considered in intervention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.