Evidence map›Paper›PMID 24838010›Full record

ArticleNature chemical biology2014

A carbonate-forming Baeyer-Villiger monooxygenase.

Youcai Hu, David Dietrich, Wei Xu, Ashay Patel, Justin A J Thuss, Jingjing Wang, Wen-Bing Yin, Kangjian Qiao, K N Houk, John C Vederas and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature chemical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 91 citations in OpenAlex.

  1. Article
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  8. Genetic Manipulation of the Brassicaceae Smut FungusJournal of fungi (Basel, Switzerland) · 2021
    Article
  9. Progress in the Chemistry of Cytochalasans.Progress in the chemistry of organic natural products · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
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  16. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Youcai HuDepartment of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, California, USA.
David DietrichDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Wei XuDepartment of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, California, USA.
Ashay PatelDepartment of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California, USA.
Justin A J ThussDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Jingjing WangDepartment of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, California, USA.
Wen-Bing Yin1] Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, California, USA. [2].
Kangjian QiaoDepartment of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, California, USA.
K N HoukDepartment of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California, USA.
John C VederasDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
Yi Tang1] Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, California, USA. [2] Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · USUniversity of Alberta · CA

Funding

CHEMISTRY BIOLOGY INTERFACE TRAINING PROGRAMT32GM008496 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYNARD, HEATHER D · 1993 to 2019
$6.3M
Rediscovering Natural Chemical Diversity -1DP1GM106413DP1GM106413 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TANG, YI · 2012 to 2016
$3.9M
Characterization and Engineering of Fungal Megasynthases in Escherichia coliR01GM085128 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TANG, YI · 2008 to 2016
$2.1M
NCCDPHP CDC HHS 1DP1GM106413NIGMS NIH HHS 1R01GM085128NIGMS NIH HHS DP1 GM106413NIGMS NIH HHS R01 GM085128NIGMS NIH HHS T32 GM008496NIGMS NIH HHS T32GM008496
6 · The paper itself

Abstract

Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase, CcsB, which catalyzes the formation of an in-line carbonate in the macrocyclic portion of cytochalasin E. This study expands the repertoire of activities of FMOs and provides a possible synthetic strategy for transformation of ketones into carbonates.

Indexed as

Gene Expression Regulation, FungalAmino Acid SequenceAspergillusCarbonatesCatalysisCytochalasinsFungal ProteinsGene Knockout TechniquesGenetic Complementation TestKetonesMixed Function OxygenasesOxidation-ReductionCarbonatescytochalasin ECytochalasinsFungal ProteinsKetonesMixed Function Oxygenases

Identifiers

PMID24838010
PMCPMC4062580
OpenAlexW2062733924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.