Evidence map›Paper›PMID 24837992›Full record

ArticleSexually transmitted infections2014

High burden of STIs among HIV-infected adults prior to initiation of ART in South Africa: a retrospective cohort study.

Mark N Lurie, Kipruto Kirwa, Johann Daniels, Marcel Berteler, Seth C Kalichman, Catherine Mathews

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sexually transmitted infections, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Population prevalence of sexually transmitted infections in a high HIV burden district in KwaZulu-Natal, South Africa: Implications for HIV epidemic control.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Mark N LurieBrown University School of Public Health, Providence, Rhode Island, USA.
Kipruto KirwaBrown University School of Public Health, Providence, Rhode Island, USA Department of Epidemiology and Nutrition, Moi University School of Public Health, Eldoret, Kenya.
Johann DanielsHealth Information and Technology, City Health, Cape Town, South Africa.
Marcel BertelerHealth Information and Technology, City Health, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-8162-3538
Seth C KalichmanDepartment of Psychology, University of Connecticut, Storrs, Connecticut, USA.
Catherine MathewsHealth Systems Research Unit, South African Medical Research Council; and the School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
City of Cape Town · ZABrown University · USRhode Island Department of Health · USSouth African Medical Research Council · ZAUniversity of Connecticut · US

Funding

Spatial Analysis CoreR24HD041020 · NICHD · BROWN UNIVERSITY · PI LOGAN, JOHN R · 2001 to 2016
$7.4M
Enhanced STI/HIV Partner Notification in South AfricaR01HD074560 · NICHD · UNIVERSITY OF CONNECTICUT STORRS · PI KALICHMAN, SETH C · 2013 to 2017
$2.8M
Impact of Antiretroviral Therapy on HIV Epidemic DynamicsR01MH083539 · NIMH · BROWN UNIVERSITY · PI LURIE, MARK NATHAN · 2009 to 2012
$2.2M
Partnerships for the Next Generation of HIV Social Science in South AfricaR24HD077976 · NICHD · BROWN UNIVERSITY · PI COLVIN, CHRISTOPHER JAMES, LURIE, MARK NATHAN · 2013 to 2017
$1.9M
NICHD NIH HHS 1R24HD077976NICHD NIH HHS R01 HD074560NICHD NIH HHS R01HD074560NICHD NIH HHS R24 HD041020NICHD NIH HHS R24 HD077976NIMH NIH HHS 1R01MH083539NIMH NIH HHS R01 MH083539
6 · The paper itself

Abstract

objectivesTo assess the burden of sexually transmitted infections (STIs) among HIV-positive South Africans in the period prior to antiretroviral therapy (ART) initiation compared with the period once on ART.

methodsWe linked the clinic records of 1465 patients currently on ART to the electronic database which records all visits to city clinics. We used a mixed effects Poisson model to assess the relative rates of occurrence of treatment seeking for an STI in the periods prior to initiation of ART and while on ART.

resultsWe accumulated 4214 person-years of follow-up, divided nearly equally between the pre-ART and on-ART periods. The rate of treatment seeking for new STIs was 5.50 (95% CI 5.43 to 5.78) per 100 person-years, and individuals had on average a sevenfold higher rate of seeking treatment for STIs in the period prior to initiating ART (9.57 per 100 person-years) compared with the period once on ART (5.5 per 100 person-years) (adjusted rate ratio (RR) 7.01, 95% CI 4.64 to 10.59). Being male (RR 1.73, 95% CI 1.18 to 2.55) or younger (age <25) (RR 2.67, 95% CI 1.53 to 4.65) was associated with higher incidence of clinic visits for STI treatment, while advanced stage of HIV disease (WHO stage 4) (RR 0.33, 95% CI 0.15 to 0.69) was associated with lower incidence.

conclusionsThe period prior to the initiation of ART is a critical period where increased attention should be focused on the detection and treatment of STIs. A successful effort to treat STIs in this period will likely reduce further HIV transmission and fits within a test-and-treat approach.

Indexed as

AdolescentAdultCohort StudiesFemaleHumansIncidenceMaleMiddle AgedPrevalenceRetrospective StudiesRisk FactorsSexually Transmitted DiseasesSouth AfricaYoung AdultAfricaAnteretroviral TherapyHIV

Identifiers

PMID24837992
PMCPMC4233167
OpenAlexW2158969742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.