ArticleSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Effects on GLP-1, PYY, and leptin by direct stimulation of terminal ileum and cecum in humans: implications for ileal transposition.
Article in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 58 citations in OpenAlex.
- The role of PYY in improving insulin resistance.Frontiers in endocrinology · 2026Review
- International expert consensus on surgery for type 2 diabetes mellitus.BMC endocrine disorders · 2025Review
- GLP-1: The Progenitor Hormone.Obesity surgery · 2025Article
- Design of Natterins-based peptides improves antimicrobial and antiviral activities.Biotechnology reports (Amsterdam, Netherlands) · 2025Article
- Peptides Used for Heavy Metal Remediation: A Promising Approach.International journal of molecular sciences · 2024Review
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- Recent Advances in Pharmaceutical Design: Unleashing the Potential of Novel Therapeutics.Current pharmaceutical biotechnology · 2024Review
- Valorization of leftover green tea residues through conversion to bioactive peptides using probiotics-aided anaerobic digestion.Microbial biotechnology · 2023Article
- Strategic Approaches to Improvise Peptide Drugs as Next Generation Therapeutics.International journal of peptide research and therapeutics · 2023Review
- In Silico Prediction of Anti-Infective and Cell-Penetrating Peptides fromPharmaceuticals (Basel, Switzerland) · 2022Article
- Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering.Bioactive materials · 2022Review
- Comparison of Meal Pattern and Postprandial Glucose Response in Duodenal Switch and Gastric Bypass Patients.Obesity surgery · 2019Article
- Rational Design of Hybrid Peptides: A Novel Drug Design Approach.Current medical science · 2019Review
- Glycyl-alanyl-histidine protects PC12 cells against hydrogen peroxide toxicity.BMC biochemistry · 2017Article
- Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications.Marine drugs · 2017Review
- Identification of a novel angiogenic peptide from periostin.PloS one · 2017Article
- Design and Synthesis of Analogues of Marine Natural Product Galaxamide, an N-methylated Cyclic Pentapeptide, as Potential Anti-Tumor Agent in Vitro.Marine drugs · 2016Article
- Changes in levels of selected incretins and appetite-controlling hormones following surgical treatment for morbid obesity.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2015Article
- Ileal effect on blood glucose, HbA1c, and GLP-1 in Goto-Kakizaki rats.Obesity surgery · 2014Article
- The evolution of metabolic/bariatric surgery.Obesity surgery · 2014Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe do not have a unified, scientifically tested theory of causation for obesity and its co-morbidities, nor do we have explanations for the mechanics of the metabolic/bariatric surgery procedures. Integral to proffered hypotheses are the actions of the hormones glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and leptin. The objective of this study was to obtain blood levels of GLP-1, PYY, and leptin after stimulation of the terminal ileum and cecum by a static infusion of a food hydrolysate in morbidly obese patients undergoing a duodenal switch procedure.
settingUniversity Hospital.
methodsPlasma levels of GLP-1, PYY, and leptin were obtained at 0, 30, 60, 90, and 120 minutes after instillation of 240 mL of a food hydrolysate into the ileum or cecum.
resultsThe mean±SD GLP-1 values by cecal stimulation for 0, 30, 60, 90, and 120 minutes were: 41.3±23.2; 39.6±21.8; 38.9±19.1; 47.4±22.3; 51.7±27.3 pM, and by ileal stimulation: 55.0±32.8; 83.4±16.1; 78.7±23.8; 84.7±23.5; 76.4±25.6. The mean±SD PYY values by cecal stimulation were: 62.1±24.8; 91.1±32.8; 102.1±39.6; 119.6±37.5; 130.3±36.7, and by ileal stimulation: 73.8±41.6; 138.1±17.7; 149.5±23.3; 165.7±24.3; 155.5±29.1. Percent change in PYY levels increased ~150%, GLP-1 increased ~50%, and leptin decreased ~20%.
conclusionDirect stimulation of the human terminal ileum and cecum by a food hydrolysate elicits significant plasma GLP-1 and PYY elevations and leptin decreases, peaking at 90-120 minutes. The ileal GLP-1 and PYY responses exceed those of the cecum, and the PYY effect is about 3-fold that of GLP-1. The results of this study question the satiety premise for ileal transposition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.