ArticleSocial cognitive and affective neuroscience2015
Out of control: evidence for anterior insula involvement in motor impulsivity and reactive aggression.
Article in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 4 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 4 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- A meta-analysis on shared and distinct neural correlates of the decision-making underlying altruistic and retaliatory punishment.Human brain mapping · 2021Pooled it
- Meta-analytic evidence for a joint neural mechanism underlying response inhibition and state anger.Human brain mapping · 2020Pooled it
- Neural networks of aggression: ALE meta-analyses on trait and elicited aggression.Brain structure & function · 2019Pooled it
- Dissociations of cognitive inhibition, response inhibition, and emotional interference: Voxelwise ALE meta-analyses of fMRI studies.Human brain mapping · 2018Pooled it
- Trial
- Cortico-limbic connectivity in MAOA-L carriers is vulnerable to acute tryptophan depletion.Human brain mapping · 2017Trial
- The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity-Related and Alcohol-Seeking Behaviors.CNS neuroscience & therapeutics · 2026Article
- Shifts in attentional demand are accompanied by sex-specific patterns of insula-frontal cortical interactions in mice.NeuroImage · 2026Article
- Epigenetic manipulation of anterior insular cortex alters neural signals and cognitive control.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Abnormal structural gray matter and structural covariance networks associated with biopsychosocial characteristics in children with multisite pain.The journal of headache and pain · 2025Article
- Motor impulsivity and spicy food craving: A mediation analysis of insula-based resting state functional connectivity.Brain imaging and behavior · 2024Article
- Effects of chronic stress on cognitive function - From neurobiology to intervention.Neurobiology of stress · 2024Review
- Resting-State Functional Connectivity Profile of Insular Subregions.Brain sciences · 2024Article
- Trait Aggression is Reflected by a Lower Temporal Stability of EEG Resting Networks.Brain topography · 2024Article
- Neural Correlates of Trait Impulsivity among Adult Healthy Individuals.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking.eNeuro · 2024Article
- Neurofeedback and meditation technology in outpatient offender treatment: a feasibility and usability pilot study.Frontiers in psychology · 2024Article
- A chemical signal in human female tears lowers aggression in males.PLoS biology · 2023Article
- Development of social feedback processing and responses in childhood: an fMRI test-replication design in two age cohorts.Social cognitive and affective neuroscience · 2023Article
- Mapping frontoinsular cortex from diffusion microstructure.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhibiting impulsive reactions while still defending one's vital resources is paramount to functional self-control and successful development in a social environment. However, this ability of successfully inhibiting, and thus controlling one's impulsivity, often fails, leading to consequences ranging from motor impulsivity to aggressive reactions following provocation. Although inhibitory failure represents the underlying mechanism, the neurocognition of social aggression and motor response inhibition have traditionally been investigated in separation. Here, we aimed to directly investigate and compare the neural mechanisms underlying the failure of inhibition across those different modalities of self-control. We used functional imaging to reveal the overlap in neural correlates between failed motor response inhibition (measured by a go/no-go task) and reactive aggression (measured by the Taylor aggression paradigm) in healthy males. The core overlap of neural correlates was located in the anterior insula, suggesting common anterior insula involvement in motor impulsivity as well as reactive aggression. This evidence regarding an overarching role of the anterior insula across different modalities of self-control enables an integrative perspective on insula function and a better integration of cognitive, social and emotional factors into a comprehensive model of impulsivity. Furthermore, it can eventually lead to a better understanding of clinical syndromes involving inhibitory deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.