ArticleThe Journal of clinical investigation2014
Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection.
Article in The Journal of clinical investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- The Many Faces of Immune Activation in HIV-1 Infection: A Multifactorial Interconnection.Biomedicines · 2023Review
- Markers of Immune Activation and Inflammation Are Associated with Higher Levels of Genetically-Intact HIV in HIV-HBV Co-Infected Individuals.Journal of virology · 2022Article
- Low Dietary Fiber Intake Links Development of Obesity and Lupus Pathogenesis.Frontiers in immunology · 2021Article
- A theoretic approach to the mode of gut microbiome translocation in SIV-infected Asian macaques.FEMS microbiology ecology · 2020Article
- Alterations in Circulating Fatty Acid Are Associated With Gut Microbiota Dysbiosis and Inflammation in Multiple Sclerosis.Frontiers in immunology · 2020Article
- Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?Metabolic brain disease · 2019Review
- Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis.Molecular neurobiology · 2018Review
- HIV as a Cause of Immune Activation and Immunosenescence.Mediators of inflammation · 2017Review
- Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection.Scientific reports · 2016Article
- Statin modulation of monocyte phenotype and function: implications for HIV-1-associated neurocognitive disorders.Journal of neurovirology · 2016Article
- Brief Report: Differential Associations of Interleukin 6 and Intestinal Fatty Acid-Binding Protein With Progressive Untreated HIV-1 Infection in Rakai, Uganda.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Stimulation of PBMC and Monocyte-Derived MacrophagesFrontiers in immunology · 2016Article
- Mucosal Regulatory T Cells and T Helper 17 Cells in HIV-Associated Immune Activation.Frontiers in immunology · 2016Article
- CD14(+) macrophages that accumulate in the colon of African AIDS patients express pro-inflammatory cytokines and are responsive to lipopolysaccharide.BMC infectious diseases · 2015Article
- Ageing with HIV: a multidisciplinary review.Infection · 2015Review
- During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ.EBioMedicine · 2015Article
- Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque.Journal of immunology research · 2015Article
- von Willebrand Factor is elevated in HIV patients with a history of thrombosis.Frontiers in microbiology · 2015Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic immune activation is a key factor in HIV-1 disease progression. The translocation of microbial products from the intestinal lumen into the systemic circulation occurs during HIV-1 infection and is associated closely with immune activation; however, it has not been determined conclusively whether microbial translocation drives immune activation or occurs as a consequence of HIV-1 infection. In an important study in this issue of the JCI, Kristoff and colleagues describe the role of microbial translocation in producing immune activation in an animal model of HIV-1 infection, SIV infection of pigtailed macaques. Blocking translocation of intestinal bacterial LPS into the circulation dramatically reduced T cell activation and proliferation, production of proinflammatory cytokines, and plasma SIV RNA levels. This study directly demonstrates that microbial translocation promotes the systemic immune activation associated with HIV-1/SIV infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.