ArticleImmunity2014
Bystander chronic infection negatively impacts development of CD8(+) T cell memory.
Article in Immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02590068 (Effects of Chronic Viral Infection on Immune Response to Zoster Vaccination), which is not on this map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Chronic Viral Infection on Immune Response to Zoster Vaccination
Who cites it
65 citing papers in PubMed.
- Regulators of CD8Nature reviews. Immunology · 2026Review
- Tissue-resident exhausted and memory CD8Nature immunology · 2026Article
- Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8bioRxiv : the preprint server for biology · 2025Article
- Comorbidities and systemic steroids drive pneumonia risk in inflammatory bowel disease: Propensity score-matched cohort study.World journal of gastrointestinal pharmacology and therapeutics · 2025Article
- Memory CD8 T cells are vulnerable to chronic IFN-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice.Nature communications · 2024Article
- Simultaneous analysis of pMHC binding and reactivity unveils virus-specific CD8 T cell immunity to a concise epitope set.Science advances · 2024Article
- Chronic viral infection impairs immune memory to a different pathogen.PLoS pathogens · 2024Article
- Single-cell profiling of the microenvironment in human bone metastatic renal cell carcinoma.Communications biology · 2024Article
- Toxoplasma gondii infection and high levels of IgE are associated to erythema nodosum leprosy (ENL).PloS one · 2024Article
- Immune mobilising T cell receptors redirect polyclonal CD8Scientific reports · 2022Article
- MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The causal relationship between obesity and skin and soft tissue infections: A two-sample Mendelian randomization study.Frontiers in endocrinology · 2022Article
- Review
- Liver-Resident Bystander CD8Gastroenterology · 2021Article
- Formation of Tissue-Resident CD8Cold Spring Harbor perspectives in biology · 2021Review
- Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients.Viruses · 2021Article
- A network of immune and microbial modifications underlies viral persistence in the gastrointestinal tract.The Journal of experimental medicine · 2020Article
- EBV-specific CD8 T lymphocytes and B cells during glatiramer acetate therapy in patients with MS.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Overcoming immunotherapeutic resistance by targeting the cancer inflammation cycle.Seminars in cancer biology · 2020Review
- Chronic viral infections impinge on naive bystander CD8 T cells.Immunity, inflammation and disease · 2020Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Epidemiological evidence suggests that chronic infections impair immune responses to unrelated pathogens and vaccines. The underlying mechanisms, however, are unclear and distinguishing effects on priming versus development of immunological memory has been challenging. We investigated whether bystander chronic infections impact differentiation of memory CD8(+) T cells, the hallmark of protective immunity against intracellular pathogens. Chronic bystander infections impaired development of memory CD8(+) T cells in several mouse models and humans. These effects were independent of initial priming and were associated with chronic inflammatory signatures. Chronic inflammation negatively impacted the number of bystander CD8(+) T cells and their memory development. Distinct underlying mechanisms of altered survival and differentiation were revealed with the latter regulated by the transcription factors T-bet and Blimp-1. Thus, exposure to prolonged bystander inflammation impairs the effector to memory transition. These data have relevance for immunity and vaccination during persisting infections and chronic inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.