Evidence map›Paper›PMID 24836855›Full record

ArticleNeuroscience2014

Physical activity, inflammation, and volume of the aging brain.

M N Braskie, C P Boyle, P Rajagopalan, B A Gutman, A W Toga, C A Raji, R P Tracy, L H Kuller, J T Becker, O L Lopez and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Frontiers in aging neuroscience · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Sleep duration and brain MRI measures: Results from the SOL-INCA MRI study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

M N BraskieImaging Genetics Center, Institute for Neuroimaging and Informatics, Dept. of Neurology, Keck/USC School of Medicine, University of Southern California, Los Angeles, CA, USA.
C P BoyleImaging Genetics Center, Institute for Neuroimaging and Informatics, Dept. of Neurology, Keck/USC School of Medicine, University of Southern California, Los Angeles, CA, USA.
P RajagopalanImaging Genetics Center, Institute for Neuroimaging and Informatics, Dept. of Neurology, Keck/USC School of Medicine, University of Southern California, Los Angeles, CA, USA.
B A GutmanImaging Genetics Center, Institute for Neuroimaging and Informatics, Dept. of Neurology, Keck/USC School of Medicine, University of Southern California, Los Angeles, CA, USA.
A W TogaImaging Genetics Center, Institute for Neuroimaging and Informatics, Dept. of Neurology, Keck/USC School of Medicine, University of Southern California, Los Angeles, CA, USA.
C A RajiDepartment of Radiology, University of California Los Angeles School of Medicine, Los Angeles, CA, USA.
R P TracyDepartments of Pathology, Biochemistry, and Center for Clinical and Translational Science, University of Vermont, Burlington, VT, USA.
L H KullerDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
J T BeckerDepartments of Neurology, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
O L LopezDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
P M ThompsonImaging Genetics Center, Institute for Neuroimaging and Informatics, Dept. of Neurology, Keck/USC School of Medicine, University of Southern California, Los Angeles, CA, USA; Depts. of Psychiatry, Engineering, Radiology, & Ophthalmology, Keck/USC School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: pthomp@usc.edu.

Funding

TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 1985 to 2019
$43.0M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KARLAMANGLA, ARUN S · 2006 to 2017
$9.8M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Predictors of Alheimers Disease in Mild Cognitive ImpairmentR01AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2002 to 2011
$3.7M
Alzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5M
Role of EIIIA fibronectin in pulmonary fibrosisR01HL085083 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WHITE, ERIC S · 2007 to 2011
$1.9M
CHS-Transition PhaseN01HC55222 · NHLBI · PI , · 2007 to 2007
$575k
Predictors of Alzheimers Disease in Mild Cognitive ImpairmentR56AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2007 to 2007
$482k
CHS-ULTRASOUND READINGN01HC045133 · HC · GEISINGER HEALTH SYSTEM · PI O'LEARY, DANIEL H. · 1994 to 2000
$155k
MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDYN01HC015103 · HC · JOHNS HOPKINS UNIVERSITY · PI BEAUCHAMP, NORMAN J · 1991 to 1998
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NHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC045133NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC55222NHLBI NIH HHS N01-HC-80007NHLBI NIH HHS N01-HC-85086NHLBI NIH HHS U01 HL080295NIA NIH HHS AG005133NIA NIH HHS AG015928NIA NIH HHS AG020098NIA NIH HHS AG040060NIA NIH HHS P30 AG028748NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005142NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG040060NIA NIH HHS R56 AG020098NIBIB NIH HHS P41 EB015922
6 · The paper itself

Abstract

Physical activity influences inflammation, and both affect brain structure and Alzheimer's disease (AD) risk. We hypothesized that older adults with greater reported physical activity intensity and lower serum levels of the inflammatory marker tumor necrosis factor α (TNFα) would have larger regional brain volumes on subsequent magnetic resonance imaging (MRI) scans. In 43 cognitively intact older adults (79.3±4.8 years) and 39 patients with AD (81.9±5.1 years at the time of MRI) participating in the Cardiovascular Health Study, we examined year-1 reported physical activity intensity, year-5 blood serum TNFα measures, and year-9 volumetric brain MRI scans. We examined how prior physical activity intensity and TNFα related to subsequent total and regional brain volumes. Physical activity intensity was measured using the modified Minnesota Leisure Time Physical Activities questionnaire at year 1 of the study, when all subjects included here were cognitively intact. Stability of measures was established for exercise intensity over 9 years and TNFα over 3 years in a subset of subjects who had these measurements at multiple time points. When considered together, more intense physical activity intensity and lower serum TNFα were both associated with greater total brain volume on follow-up MRI scans. TNFα, but not physical activity, was associated with regional volumes of the inferior parietal lobule, a region previously associated with inflammation in AD patients. Physical activity and TNFα may independently influence brain structure in older adults.

Indexed as

AgedAged, 80 and overAgingAlzheimer DiseaseApolipoproteins EBrainFemaleHumansInflammationLongitudinal StudiesMagnetic Resonance ImagingMaleMotor ActivityNeuroimmunomodulationNeuropsychological TestsOrgan SizeApolipoproteins ETumor Necrosis Factor-alphaAlzheimer’s diseaseexerciseinferior parietal lobuleMRIsupramarginal gyrustumor necrosis factor (TNFα)

Identifiers

PMID24836855
PMCPMC4076831

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.