Evidence map›Paper›PMID 24836729›Full record

ReviewPharmacology & therapeutics2014

Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia.

Rae R Matsumoto, Michael J Seminerio, Ryan C Turner, Matthew J Robson, Linda Nguyen, Diane B Miller, James P O'Callaghan

Abstract readReview
In one paragraph

Review in Pharmacology & therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Heat exposure and drug overdose mortality in the USA.Addiction (Abingdon, England) · 2026
    Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rae R MatsumotoDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA. Electronic address: rmatsumoto@hsc.wvu.edu.
Michael J SeminerioDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Ryan C TurnerCenter for Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA; Department of Neurosurgery, School of Medicine, West Virginia University, Morgantown, WV 26506,USA.
Matthew J RobsonDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Linda NguyenDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Diane B MillerCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
James P O'CallaghanCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.

Funding

TRAINING PROGRAM IN ION CHANNEL AND TRANSPORTER BIOLOGYT32NS007491 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENTON, JEROD S. · 2001 to 2020
$4.1M
Research Training Program in the Behavioral and Biomedical SciencesT32GM081741 · NIGMS · WEST VIRGINIA UNIVERSITY · PI BERREBI, ALBERT S, SIMPKINS, JAMES W. · 2008 to 2018
$2.1M
Synthesis &Evaluation of Cocaine AntagonistsR01DA013978 · NIDA · WEST VIRGINIA UNIVERSITY · PI MATSUMOTO, RAE R · 2001 to 2010
$1.9M
Intramural CDC HHS CC999999NIDA NIH HHS DA013978NIDA NIH HHS R01 DA013978NIGMS NIH HHS GM081741NIGMS NIH HHS T32 GM081741NINDS NIH HHS NS007491NINDS NIH HHS T32 NS007491
6 · The paper itself

Abstract

Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine.

Indexed as

AnimalsBody TemperatureBody Temperature RegulationCentral Nervous System StimulantsDopamineDrug OverdoseFeverHumansMethamphetamineCentral Nervous System StimulantsDopamineMethamphetamineAutonomic nervous systemHyperthermiaMethamphetamineReactive oxygen speciesThermoregulationToxicity

Identifiers

PMID24836729
PMCPMC4700537

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.